Correlation Between Activated Clotting Time and Activated Partial Thromboplastin Time During Endovascular Treatment of Cerebral Aneurysms英文文献资料.docVIP

Open Journal of Anesthesiology, 2012, 2, 1-6 1 /10.4236/ojanes.2012.21001 Published Online January 2012 (http://www.SciRP.org/journal/ojanes) Correlation between Activated Clotting Time and Activated Partial Thromboplastin Time During Endovascular Treatment of Cerebral Aneurysms David Faraoni , Benjamin Mine , Wael Nabhan , Pierre Nokerman , Yvon Deryck , Michel Baurain , 1 2 3 3 3 3 2 Boris Lubicz 1 Department of Anesthesiology, Centre Hospitalier Universitaire Brugmann—HUDERF, Université Libre de Bruxelles, Brussels, Department of Anesthesiology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium; Depart- 3 Belgium; 2 ment of Diagnostic Interventional Neuroradiology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. Email: David.FARAONI@huderf.be Received November 15 , 2011; revised December 17 , 2011; accepted December 26 , 2011 th th th ABSTRACT Purpose: Endovascular treatment (EVT) of intracranial aneurysms (IA) requires a continuous anticoagulation to avoid thromboembolic complications. In order to monitor the anticoagulation, different tests may be used including the acti- vated clotting time (ACT) and the activated partial thromboplastin time (APTT). The aim of this study was to compare ACT and APTT for the monitoring of the anticoagulation during EVT of IA. Methods: Patients referred for EVT of an IA were included. After induction, baseline ACT and APTT were recorded, followed by a bolus infusion of unfraction- ated heparin (50 UI?kg ). The same tests were controlled five minutes later with the purpose of doubling