Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells英文文献资料.docVIP

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Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells英文文献资料.doc

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Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells英文文献资料

HindawiPublishingCorporation AdvancesinVirology Volume2012,ArticleID702839,14pages doi:10.1155/2012/702839 ReviewArticle DecipheringtheMultifacetedRelationshipbetween OncolyticVirusesandNaturalKillerCells ChristopherA.Alvarez-Breckenridge,1,2JianhuaYu,3BalveenKaur, 2,3 andE.AntonioChiocca 2,3 MichaelA.Caligiuri, 3 1 2 MedicalScientistTrainingProgram,TheOhioStateUniversity,Columbus,OH43210,USA DardingerLaboratoryforNeuro-OncologyandNeurosciences,DepartmentofNeurologicalSurgery,TheOhioStateUniversity, Columbus,OH43210,USA 3 TheOhioStateUniversityComprehensiveCancerCenter,TheOhioStateUniversity,WisemanHall,400West12thAvenue, Columbus,OH43210,USA CorrespondenceshouldbeaddressedtoE.AntonioChiocca,ea.chiocca@ Received28June2011;Accepted14September2011 AcademicEditor:UlrichM.Lauer Copyright?2012ChristopherA.Alvarez-Breckenridgeetal. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the originalworkisproperlycited. Despiteactiveresearchinvirotherapy,thisapparentlysafemodalityhasnotachievedwidespreadsuccess.Theimmuneresponseto viralinfectionappearstobeanessentialfactorthatdeterminesthee?cacyofoncolyticviraltherapy.Thechallengeisdetermining whethertheviral-elicitedimmuneresponseisahindranceoratoolforviraltreatment.NKcellsareakeycomponentofinnate immunitythatmediatesantiviralimmunitywhilealsocoordinatingtumorclearance.VariousreportshavesuggestedthattheNK responsetooncolyticviraltherapyisacriticalfactorinprematureviralclearancewhilealsomediatingdownstreamantitumor immunity.Asaresult,particularattentionshouldbegiventotheNKcellresponsetovariousoncolyticviralvectorsandhowtheir antiviralpropertiescanbesuppressedwhilemaintainingtumorclearance.Inthisreviewwediscussthecurrentliteratureonthe NKresponsetooncolyticviralinfectionandhowfuturestudiesclarifythisintricateresponse. 1.Introduction the natural killer (NK) cell response to various oncolytic viruseshas