Decomposition of S-Nitrosothiols Induced by UV and Sunlight英文文献资料.docVIP

HindawiPublishingCorporation AdvancesinPhysicalChemistry Volume2009,ArticleID890346,5pages doi:10.1155/2009/890346 ResearchArticle DecompositionofS-NitrosothiolsInducedbyUVandSunlight andC.T.Aravindakumar ManojM.Veleeparampil,1,2UshaK.Aravind,1 1 1 2 SchoolofChemicalSciences,MahatmaGandhiUniversity,Kottayam,Kerala686560,India DepartmentofPharmacologyandToxicology,WilliamLevineHall,RutgersUniversity,NJ08854,USA CorrespondenceshouldbeaddressedtoC.T.Aravindakumar,ct-aravindakumar@ Received21June2009;Accepted12October2009 RecommendedbyMichaelD.Sevilla Photochemical release of nitric oxide (NO) from the S-nitroso derivatives of glutathione, L-cysteine, N-acetyl-L-cysteine, L- cysteinemethylester,D,L-penicillamine,N-acetyl-D,L-penicillamine,andN-acetylcysteaminehasbeeninvestigatedatneutraland acidicpH.ThereleaseofNOfromRSNOisoneofthekeyreactionsthatcouldbeutilizedinphotodynamictherapy.TheUV- VISandHPLCanalyseshaveshownthatunderargonsaturatedconditions,disul?de(RSSR)isthemajorproductofUVaswell assunlightinduceddecomposition.Whileinaeratedconditions,nitirite—theendproductoftheoxidationofNO—wasalso observedalongwithdisul?de.Theformationofthiylradicalastheintermediatewasrecon?rmedbylaser?ashphotolysis.The initialrateofformationofNOwasontheorderof10?5dm3mol?1s?1.Thequantumyieldsofthesereactionswereintherange of 0.2–0.8. The high quantum yields observed in the photo induced release of NO from RSNO using both UV and sunlight demonstratethepotentialapplicationofthesereactionsinphotodynamictherapy. Copyright?2009ManojM.Veleeparampiletal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. 1.Introduction the photochemo-therapeutic application of GSNO is also availableusingvisiblelightphotolysis[14]. S-Nitrosothiols (RSNO) are generally believed as the bio reservoir for nitric oxide (NO) in a biological sy