低占空比下高强度聚焦脉冲超声的可控体内热疗效应.PDFVIP

代表作3 ： Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles, Appl. Phys. Lett., 2012 年9 月, 101: 124102. （第一作者）（影 响因子3.794， 他引2 次） 摘要翻译： 低占空比下高强度聚焦脉冲超声的可控体内热疗效应 高强度聚焦超声热疗是极具发展前景癌症治疗手段之一。为了研究不同占空 比下高强度聚焦脉冲超声在兔耳静脉血管内产生的热疗效应，本文使用声—生物 体热传导—血流耦合模型对其进行了模拟方正，并进行了体内热电偶测量。实验 结果表明，高强度聚焦脉冲超声在兔耳静脉血管内产生的温升与其占空比大小成 正相关。数值仿真结果显示，可使兔耳静脉血管壁温度超过 44 ℃的脉冲超声的 占空比阈值为 6.9% 。然而在实际应用中，不同的组织深度和组织内含物可能对 占空比阈值产生不同程度的影响。本文的研究结果表明，通过调节高强度聚焦脉 冲超声占空比，我们可以在活体动物血管中实现实现可控热疗的同时尽量避免血 管周围正常组织的热损伤。 APPLIED PHYSICS LETTERS 101, 124102 (2012) Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles Juan Tu,1 Joo Ha Hwang,2 Tao Chen,1 Tingbo Fan,1 Xiasheng Guo,1 Lawrence A. Crum,2 and Dong Zhang1,a) 1 Key Laboratory of Modern Acoustics (Nanjing University), Ministry of Education, Nanjing, Jiangsu 210093, China 2Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington 98105, USA (Received 21 July 2012; accepted 4 September 2012; published online 18 September 2012) High intensity focused ultrasound (HIFU)-induced hyperthermia is a promising tool for cancer therapy. Three-dimensional nonlinear acoustic-bioheat transfer-blood flow-coupling model simulations and in vivo thermocouple measurements were performed to study hyperthermia effects in rabbit auricular vein exposed to pulsed HIFU (pHIFU) at varied duty cycles (DCs). pHIFU-induced temperature elevations are shown to increase with increasing DC. A critical DC of 6.9% is estimated