IntensityModulatedRadiationTherapy(IMRT)ForSoft调强放射治疗（IMRT）软.pptVIP

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IntensityModulatedRadiationTherapy(IMRT)ForSoft调强放射治疗（IMRT）软.ppt

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IntensityModulatedRadiationTherapy(IMRT)ForSoft调强放射治疗（IMRT）软

Intensity Modulated Radiation Therapy For Soft Tissue Sarcoma Of The Extremity: Preliminary Results KM Alektiar, L Hong, MF Brennan, S Singer. Memorial Sloan-Kettering Cancer Center Conventional RT vs. IMRT Planning Tumor Volume (PTV) DVH: Femur DVH: Soft Tissue Purpose To determine the feasibility of IMRT in locally advanced STS of the extremity To report on treatment related toxicity and tumor control Patients # pts: 10 Site: Extremity Presentation: Primary STS Time period: 03/02- 10/03 Mean age: 58 (range: 40-76) Sex: 6F/4M Tumors Characteristics Grade: High (7/10) Depth: Deep (10/10) Median size: 17 cm (9/10, 10 cm) Site: Lower extremity (9/10) Sub-site: Thigh (7/10) Knee, leg, shoulder Surgery Complete gross resection: 10/10 Positive/close margin: 4/10 Periosteal stripping/bone resection: 6/10 Neurolysis/nerve resection: 6/10 Tissue transfer for wound closure: 2/10 Indications For IMRT Indications For IMRT IMRT Characteristics Complications Fracture Significant wound complications Joint stiffness Peripheral nerve damage Edema Fracture Median F/U: 13 months (range: 6-22) None of the patients developed a fracture Significant Wound Complications Joint Stiffness (RTOG) Peripheral Nerve Damage? Edema (CTC) Tumor Control Median F/U: 13 months Local recurrence: 0/10 Distant relapse: 2/10 Death: 2/10 Conclusion IMRT is feasible for STS of the extremity Initial results suggest limited morbidity and excellent local control Longer follow/up is still needed to confirm these encouraging results in a difficult group of high-risk patients Weekly Status Check Follow/up Forms PET Scan For STS Conventional RT vs. IMRT C