8p22 MTUS1 Gene Product ATIP3 Is a Novel Anti-Mitotic Protein Underexpressed in Invasive Breast Carcinoma of Poor Prognosis 英文参考文献.docVIP

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8p22 MTUS1 Gene Product ATIP3 Is a Novel Anti-Mitotic Protein Underexpressed in Invasive Breast Carcinoma of Poor Prognosis 英文参考文献.doc

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8p22 MTUS1 Gene Product ATIP3 Is a Novel Anti-Mitotic Protein Underexpressed in Invasive Breast Carcinoma of Poor Prognosis 英文参考文献

8p22MTUS1GeneProductATIP3IsaNovelAnti-Mitotic ProteinUnderexpressedinInvasiveBreastCarcinomaof PoorPrognosis SylvieRodrigues-Ferreira1,AnneDiTommaso1,ArianeDimitrov2,SylvieCazaubon1,Nade`geGruel3,4, He′le`neColasson1,Andre′ Nicolas5,NathalieChaverot1,VincentMolinie′6,FabienReyal2 ,Brigitte Sigal-Zafrani4,5,BenoitTerris7,OlivierDelattre3,4,Franc?oisRadvanyi2,FranckPerez2 ,Anne Vincent-Salomon4,5,ClaraNahmias1* 1InstitutCochin,Universite′ ParisDescartes,InsermU567,CNRSUMR8104,Paris,France,2CNRSUMR144,InstitutCurie,Paris,France,3InsermU830,InstitutCurie,Paris, France, 4Translational Research Department, Institut Curie, Paris, France, 5Pathology Department, Hopital Curie, Paris, France, 6Pathology Department, Hopital St. Joseph,Paris,France,7PathologyDepartment,HopitalCochin,Paris,France Abstract Background:Breastcancerisaheterogeneousdiseasethatisnottotallyeradicatedbycurrenttherapies.Theclassification ofbreasttumorsintodistinctmolecularsubtypesbygeneprofilingandimmunodetectionofsurrogatemarkershasproven useful for tumor prognosis and prediction of effective targeted treatments. The challenge now is to identify molecular biomarkersthatmaybeoffunctionalrelevanceforpersonalizedtherapyofbreasttumorswithpooroutcomethatdonot respond to available treatments. The Mitochondrial Tumor Suppressor (MTUS1) gene is an interesting candidate whose expression is reduced in colon, pancreas, ovary and oral cancers. The present study investigates the expression and functionaleffectsofMTUS1geneproductsinbreastcancer. MethodsandFindings:Bymeansofgenearrayanalysis,real-timeRT-PCRandimmunohistochemistry,weshowherethat MTUS1/ATIP3issignificantlydown-regulatedinaseriesof151infiltratingbreastcancercarcinomasascomparedtonormal breasttissue.LowlevelsofATIP3correlatewithhighgradeofthetumorandtheoccurrenceofdistantmetastasis.ATIP3 levelsarealsosignificantlyreducedintriplenegative(ER-PR-HER2-)breastcarcinomas,asubgroupofhighlyproliferative tumorswithpooroutcomeandnoavailabletargetedtherapy.Funct