A Blueprint for Real-Time Functional Mapping via Human Intracranial Recordings 英文参考文献.docVIP

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A Blueprint for Real-Time Functional Mapping via Human Intracranial Recordings 英文参考文献.doc

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A Blueprint for Real-Time Functional Mapping via Human Intracranial Recordings 英文参考文献

ABlueprintforReal-TimeFunctionalMappingviaHuman IntracranialRecordings Jean-PhilippeLachaux1,2*,KarimJerbi1,2,3,OlivierBertrand1,2,LorellaMinotti4,DominiqueHoffmann5,BenjaminSchoendorff1 ,Philippe Kahane4 1INSERM, U821, Lyon, F-69500, France, 2Institut Fe′de′ratif des Neurosciences, Lyon, F-69000, France; Universite′ Lyon 1, Lyon, F-69000, France, 3LaboratoiredePhysiologiedelaPerceptionetdel’Action,CNRS,Colle`gedeFrance,Paris,France,4DepartmentofNeurologyandINSERMU704, GrenobleHospital,Grenoble,France,5DepartmentofNeurosurgeryandINSERMU318,GrenobleHospital,Grenoble,France Background. The surgical treatment of patients with intractable epilepsy is preceded by a pre-surgical evaluation period duringwhichintracranialEEGrecordingsareperformedtoidentifytheepileptogenicnetworkandprovideafunctionalmapof eloquent cerebralareas thatneed tobe sparedtominimize the risk ofpost-operative deficits. Agrowingbody ofresearch basedonsuchinvasiverecordingsindicatesthatcorticaloscillationsatvariousfrequencies,especiallyinthegammarange(40 to 150Hz), can provide efficient markers of task-related neural network activity. Principal Findings. Here we introduce anovelreal-timeinvestigationframeworkformappinghumanbrainfunctionsbasedononlinevisualizationofthespectral poweroftheongoingintracranialactivity.Theresultsobtainedwiththefirsttwoimplantedepilepsypatientswhousedthe proposedonlinesystemillustrateitsfeasibilityandutilitybothforclinicalapplications,asacomplementarytooltoelectrical stimulation for presurgical mapping purposes, and for basic research, as an exploratory tool used to detect correlations between behavior and oscillatory power modulations. Furthermore, our findings suggest a putative role for high gamma oscillations in higher-order auditory processing involved in speech and music perception. Conclusion/Significance. The proposed real-time setup is a promising tool for presurgical mapping, the investigation of functional brain dynamics, and possiblyforneurofeedbacktrainingand