A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus 英文参考文献.docVIP

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A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus 英文参考文献.doc

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A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus 英文参考文献

AGeneticandFunctionalRelationshipbetweenTCells andCellularProliferationintheAdultHippocampus Guo-JenHuang1,AdrianL.Smith2,DanielH.D.Gray3,CormacCosgrove4,BenjaminH.Singer5, AndrewEdwards1,StuartSim4,JackM.Parent5,AlyssaJohnsen3,RichardMott1,DianeMathis3, PaulKlenerman4,ChristopheBenoist3,JonathanFlint1* 1WellcomeTrustCentreforHumanGenetics,UniversityofOxford,Oxford,UnitedKingdom,2DepartmentofZoology,UniversityofOxford,Oxford,UnitedKingdom, 3SectiononImmunologyandImmunogenetics,JoslinDiabetesCenterandDepartmentofPathology,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesof America,4PeterMedawarBuildingforPathogenResearch,NuffieldDepartmentofMedicine,UniversityofOxford,Oxford,UnitedKingdom,5DepartmentofNeurology, UniversityofMichigan,AnnArbor,Michigan,UnitedStatesofAmerica Abstract Neurogenesiscontinuesthroughtheadultlifeofmiceinthesubgranularzoneofthedentategyrusinthehippocampus, butitsfunctionremainsunclear.Measuringcellularproliferationinthehippocampusof719outbredheterogeneousstock mice revealed a highly significant correlation with the proportions of CD8+ versus CD4+ T lymphocyte subsets. This correlation reflected shared genetic loci, with the exception of the H-2Ea locus that had a dominant influence on T cell subsetsbutnoimpactonneurogenesis.AnalysisofknockoutsandrepopulationofTCRa-deficientmicebysubsetsofTcells confirmedtheinfluenceofTcellsonadultneurogenesis,indicatingthatCD4+Tcellsorsubpopulationsthereofmediatethe effect. Our results reveal an organismal impact, broader than hitherto suspected, of the natural genetic variation that controlsTcelldevelopmentandhomeostasis. Citation:HuangG-J,SmithAL,GrayDHD,CosgroveC,SingerBH,etal.(2010)AGeneticandFunctionalRelationshipbetweenTCellsandCellularProliferationin theAdultHippocampus.PLoSBiol8(12):e1000561.doi:10.1371/journal.pbio.1000561 AcademicEditor:TheoD.Palmer,StanfordUniversity,UnitedStatesofAmerica ReceivedJuly5,2010;AcceptedOctober28,2010;PublishedDecember14,2010 Copyright: ? 2010 Huang et al. This is