A Molecular Epidemiology Survey of Respiratory Adenoviruses Circulating in Children Residing in Southern Palestine 英文参考文献.docVIP

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A Molecular Epidemiology Survey of Respiratory Adenoviruses Circulating in Children Residing in Southern Palestine 英文参考文献.doc

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A Molecular Epidemiology Survey of Respiratory Adenoviruses Circulating in Children Residing in Southern Palestine 英文参考文献

AMolecularEpidemiologySurveyofRespiratory AdenovirusesCirculatinginChildrenResidingin SouthernPalestine LinaQurei1,DonaldSeto2,ZaidounSalah1,MaysaAzzeh1* 1VirologyResearchLaboratory,MedicalResearchCenter,Al-QudsUniversity,EastJerusalem-AbuDies,Palestine,2SchoolofSystemsBiology,GeorgeMasonUniversity, Manassas,Virginia,UnitedStatesofAmerica Abstract Amolecularepidemiologysurveywasperformedinordertoestablishanddocumenttherespiratoryadenoviruspathogen profilesamongchildreninSouthernPalestine.Threehundredandthirty-eighthospitalizedpediatriccaseswithadenovirus- associatedrespiratorytractinfectionswereanalyzed.Fortyfourcasesoutofthe338wereevaluatedinmoredetailforthe adenoviruses types present. All of the children resided in Southern Palestine, that is, in city, village and refugee camp environmentswithinthedistrictsofHebronandBethlehem.Humanadenovirusescirculatedthroughout2005–2010,with majoroutbreaksoccurringinthespringmonths.Alargerpercentofthechildrendiagnosedwithadenoviralinfectionswere maleinfants.DNAsequenceanalysisofthehexongenesfrom44samplesrevealedthatseveraldistinctadenovirustypes circulated in the region; these were HAdV-C1, HAdV-C2, HAdV-B3 and HAdV-C5. However, not all of these types were detected within each year. This is the first study ever conducted in Palestine of the genetic epidemiology of respiratory adenovirusinfections. Citation:QureiL,SetoD,SalahZ,AzzehM(2012)AMolecularEpidemiologySurveyofRespiratoryAdenovirusesCirculatinginChildrenResidinginSouthern Palestine.PLoSONE7(8):e42732.doi:10.1371/journal.pone.0042732 Editor:EricJ.Kremer,FrenchNationalCentreforScientificResearch,France ReceivedMarch22,2012;AcceptedJuly10,2012;PublishedAugust3,2012 Copyright: ? 2012 Qurei et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: Supportfor thisworkcame,in part, fromtheinternal r