A Novel Gene, fudoh, in the SCCmec Region Suppresses the Colony Spreading Ability and Virulence of Staphylococcus aureus 英文参考文献.docVIP

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A Novel Gene, fudoh, in the SCCmec Region Suppresses the Colony Spreading Ability and Virulence of Staphylococcus aureus 英文参考文献.doc

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A Novel Gene, fudoh, in the SCCmec Region Suppresses the Colony Spreading Ability and Virulence of Staphylococcus aureus 英文参考文献

ANovelGene,fudoh,intheSCCmecRegionSuppresses theColonySpreadingAbilityandVirulenceof Staphylococcusaureus ChikaraKaito1,YosukeOmae1,YasuhikoMatsumoto1,MakikoNagata1,HirokiYamaguchi2,TaijiAoto3, TeruyoIto4,KeiichiHiramatsu4,KazuhisaSekimizu1* 1Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan, 2Division of Hematology, Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan, 3Department of Central Laboratory, Nippon Medical School, Bunkyo-ku, Tokyo, Japan,4DepartmentofInfectionControlScience,FacultyofMedicine,JuntendoUniversity,Bunkyo-ku,Tokyo,Japan Abstract Staphylococcus aureus colonies can spread on soft agar plates. We compared colony spreading of clinically isolated methicillin-sensitiveS.aureus(MSSA)andmethicillin-resistantS.aureus(MRSA).AllMSSAstrainsshowedcolonyspreading, butmostMRSAstrains(73%)carryingSCCmectype-IIshowedlittlecolonyspreading.DeletionoftheentireSCCmectype-II regionfromtheseMRSAstrainsrestoredcolonyspreading.Introductionofanovelgene,fudoh,carriedbySCCmectype-II intoNewmanstrainsuppressedcolonyspreading.MRSAstrainswithhighspreadingability(27%)hadnofudohorapoint- mutated fudoh that did not suppress colony spreading. The fudoh-transformed Newman strain had decreased exotoxin productionandattenuatedvirulenceinmice.Mostcommunity-acquiredMRSAstrainscarriedSCCmectype-IV,whichdoes not include fudoh, and showed high colony spreading ability. These findings suggest that fudoh in the SCCmec type-II regionsuppressescolonyspreadingandexotoxinproduction,andisinvolvedinS.aureuspathogenesis. Citation:KaitoC,OmaeY,MatsumotoY,NagataM,YamaguchiH,etal.(2008)ANovelGene,fudoh,intheSCCmecRegionSuppressestheColonySpreading AbilityandVirulenceofStaphylococcusaureus.PLoSONE3(12):e3921.doi:10.1371/journal.pone.0003921 Editor:ChristopheHerman,BaylorCollegeofMedicine,UnitedStatesofAmerica ReceivedAugust22,2008;AcceptedNovember13,2008;PublishedDecember11,2008 Copyright: