A Novel Insight into the Oxidoreductase Activity of Helicobacter pylori HP0231 Protein 英文参考文献.docVIP

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A Novel Insight into the Oxidoreductase Activity of Helicobacter pylori HP0231 Protein 英文参考文献.doc

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A Novel Insight into the Oxidoreductase Activity of Helicobacter pylori HP0231 Protein 英文参考文献

ANovelInsightintotheOxidoreductaseActivityof HelicobacterpyloriHP0231Protein PaulaRoszczenko1,2,KatarzynaA.Radomska1,EwaWywial3,Jean-FrancoisCollet4,5,6, ElzbietaK.Jagusztyn-Krynicka1* 1DepartmentofBacterialGenetics,InstituteofMicrobiology,theUniversityofWarsaw,Warsaw,Poland,2CollegeofInter-FacultyIndividualStudiesinMathematicsand NaturalSciences,theUniversityofWarsaw,Warsaw,Poland,3LaboratoryofBioinformaticsandProteinEngineering,InternationalInstituteofMolecularandCellBiology, Warsaw,Poland,4WELBIO(WalloonExcellenceinLifeSciencesandBiotechnology),Universite′ CatholiquedeLouvain,Brussels,Belgium,5deDuveInstitute,Universite′ CatholiquedeLouvain,Brussels,Belgium,6BrusselsCenterforRedoxBiology,Brussels,Belgium Abstract Background: Theformationofadisulfidebondbetweentwocysteineresiduesstabilizesproteinstructure.Althoughwe now have a good understanding of the Escherichia coli disulfide formation system, the machineries at work in other bacteria,includingpathogens,arepoorlycharacterized.Thus,theobjectiveofthisworkwastoimproveourunderstanding ofthedisulfideformationmachineryofHelicobacterpylori,aleadingcauseofulcersandariskfactorforstomachcancer worldwide. Methods and Results: The protein HP0231 from H. pylori, a structural counterpart of E. coli DsbG, is the focus of this research. Its function was clarified by using a combination of biochemical, microbiological and genetic approaches. In particular,wedeterminedthebiochemicalpropertiesofHP0231aswellasitsredoxstateinH.pyloricells. Conclusion:AltogetherourresultsshowthatHP0231isanoxidoreductasethatcatalyzesdisulfidebondformationinthe periplasm.WeproposetocallitHpDsbA. Citation:RoszczenkoP,RadomskaKA,WywialE,ColletJ-F,Jagusztyn-KrynickaEK(2012)ANovelInsightintotheOxidoreductaseActivityofHelicobacterpylori HP0231Protein.PLoSONE7(10):e46563.doi:10.1371/journal.pone.0046563 Editor:YoshioYamaoka,VeteransAffairsMedicalCenter(111D),UnitedStatesofAmerica ReceivedJune17,2012;AcceptedAugust31,2012;PublishedOctober3,2012 Copyri