A Water Soluble CoQ10 Formulation Improves Intracellular Distribution and Promotes Mitochondrial Respiration in Cultured Cells 英文参考文献.docVIP
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A Water Soluble CoQ10 Formulation Improves Intracellular Distribution and Promotes Mitochondrial Respiration in Cultured Cells 英文参考文献
AWaterSolubleCoQ10 FormulationImproves
IntracellularDistributionandPromotesMitochondrial
RespirationinCulturedCells
ChristianBergamini1,NoahMoruzzi1,AntonellaSblendido2,GiorgioLenaz1,RomanaFato1*
1DepartmentofBiochemistry‘‘G.Moruzzi’’,UniversityofBologna,Bologna,Italy,2ScharperTherapeutics,MedicalDepartment,SestoS.Giovanni,Milano,Italy
Abstract
Background:Mitochondriaareboththecellularpowerhouseandthemajorsourceofreactiveoxygenspecies.Coenzyme
Q10playsakeyroleinmitochondrialenergyproductionandisrecognizedasapowerfulantioxidant.Forthesereasonsit
can be argued that higher mitochondrial ubiquinone levels may enhance the energy state and protect from oxidative
stress.DespitethelargenumberofclinicalstudiesontheeffectofCoQ10supplementation,thereareveryfewexperimen-
tal data about the mitochondrial ubiquinone content and the cellular bioenergetic state after supplementation.
Controversialclinicalandinvitroresultsaremainlyduetothehighhydrophobicityofthiscompound,whichreducesits
bioavailability.
PrincipalFindings:Wemeasuredthecellularandmitochondrialubiquinonecontentintwocelllines(T67andH9c2)after
supplementationwithahydrophilicCoQ10formulation(QterH)andnativeCoQ10.Ourresultsshowthatthewatersoluble
formulation is more efficient in increasing ubiquinone levels. We have evaluated the bioenergetics effect of ubiquinone
treatment, demonstrating that intracellular CoQ10 content after Qter supplementation positively correlates with an
improvedmitochondrialfunctionality(increasedoxygenconsumptionrate,transmembranepotential,ATPsynthesis)and
resistancetooxidativestress.
Conclusions:TheimprovedcellularenergymetabolismrelatedtoincreasedCoQ10contentrepresentsastrongrationalefor
theclinicaluseofcoenzymeQ10andhighlightsthebiologicaleffectsofQterH,thatmakeittheeligibleCoQ10
fortheubiquinonesupplementation.
formulation
Citation: Bergamini C, MoruzziN, SblendidoA, Lenaz G, Fato R(2012) AWater SolubleCoQ10 FormulationImproves Intracellular Distribution and Promotes
MitochondrialRespiratio
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