Abnormal Brain Default-Mode Network Functional Connectivity in Drug Addicts 英文参考文献.docVIP

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Abnormal Brain Default-Mode Network Functional Connectivity in Drug Addicts 英文参考文献.doc

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Abnormal Brain Default-Mode Network Functional Connectivity in Drug Addicts 英文参考文献

AbnormalBrainDefault-ModeNetworkFunctional ConnectivityinDrugAddicts NingMa1*.,YingLiu2.,Xian-MingFu3,NanLi1,Chang-XinWang2,HaoZhang4,Ruo-BingQian3 ,Hu- ShengXu1,XiaopingHu5,Da-RenZhang1 1CASKeyLaboratoryofBrainFunctionandDisease,andSchoolofLifeSciences,UniversityofScienceandTechnologyofChina,Hefei,China,2DepartmentofMRIat ProvincialHospitalAffiliatedtoAnhuiMedicalUniversity,Hefei,China,3DepartmentofNeurosurgeryatProvincialHospitalAffiliatedtoAnhuiMedicalUniversityand AnhuiProvincialInstituteofStereotacticNeurosurgery,Hefei,China,4AnhuiDetoxificationandRehabilitationCenter,Hefei,China,5TheWallaceH.CoulterDepartment ofBiomedicalEngineering,GeorgiaInstituteofTechnologyandEmoryUniversity,Atlanta,Georgia,UnitedStatesofAmerica Abstract Background:Thedefaultmodenetwork(DMN)isasetofbrainregionsthatexhibitsynchronizedlowfrequencyoscillations at resting-state, and is believed to be relevant to attention and self-monitoring. As the anterior cingulate cortex and hippocampusareimpairedindrugaddictionandmeanwhilearepartsoftheDMN,thepresentstudyexaminedaddiction- relatedalterationoffunctionalconnectivityoftheDMN. Methodology:Resting-statefunctionalmagneticresonanceimagingdataofchronicheroinusers(14males,age:30.165.3 years,rangefrom22to39years)andnon-addictedcontrols(13males,age:29.867.2years,rangefrom20to39years)were investigatedwithindependentcomponentanalysistoaddresstheirfunctionalconnectivityoftheDMN. PrincipalFindings:Comparedwithcontrols,heroinusersshowedincreasedfunctionalconnectivityinrighthippocampus anddecreasedfunctionalconnectivityinrightdorsalanteriorcingulatecortexandleftcaudateintheDMN. Conclusions: These findings suggest drug addicts’ abnormal functional organization of the DMN, and are discussed as addiction-relatedabnormallyincreasedmemoryprocessingbutdiminishedcognitivecontrolrelatedtoattentionandself- monitoring,whichmayunderliethehypersensitivitytowarddrugrelatedcuesbutweakenedstrengthofcognitivecontrol inthestateofaddiction. Citation: Ma N, Liu Y, Fu X-M,