Active and Passive Immunization with rHyr1p-N Protects Mice against Hematogenously Disseminated Candidiasis 英文参考文献.docVIP

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Active and Passive Immunization with rHyr1p-N Protects Mice against Hematogenously Disseminated Candidiasis 英文参考文献.doc

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Active and Passive Immunization with rHyr1p-N Protects Mice against Hematogenously Disseminated Candidiasis 英文参考文献

ActiveandPassiveImmunizationwithrHyr1p-NProtects MiceagainstHematogenouslyDisseminatedCandidiasis GuanpingshengLuo1,AshrafS.Ibrahim1,2,SamuelW.French2,3,JohnE.Edwards Jr.1,2,YueFu1,2 * 1DivisionofInfectiousDiseases,LosAngelesBiomedicalResearchInstituteatHarbor-UCLAMedicalCenter,Torrance,California,UnitedStatesofAmerica,2DavidGeffen SchoolofMedicineatUCLA,LosAngeles,California,UnitedStatesofAmerica,3DepartmentofPathology,LosAngelesBiomedicalResearchInstituteatHarbor-UCLA MedicalCenter,Torrance,California,UnitedStatesofAmerica Abstract WepreviouslyreportedthatCandidaalbicanscellsurfaceproteinHyr1encodesaphagocytekillingresistancefactorand activevaccinationwitharecombinantN-terminusofHyr1protein(rHyr1p-N),significantlyprotectsimmunocompetentmice from disseminated candidiasis. Here we report the marked efficacy of rHyr1p-N vaccine on improving the survival and reducingthefungalburdenofdisseminatedcandidiasisinbothimmunocompetentandimmunocompromisedmiceusing theFDA-approved adjuvant, alum.Importantly, wealso showthat pooled rabbit anti-Hyr1p polyclonal antibodies raised against 8 different peptide regions of rHyr1p-N protected mice in a hematogenously disseminated candidiasis model, raisingthepossibilityofdevelopingasuccessfulpassiveimmunotherapystrategytotreatthisdisease.Ourdatasuggest that the rabbit anti-Hyr1p antibodies directly neutralized the Hyr1p virulence function, rather than enhanced opsonophagocytosis for subsequent killing by neutrophil in vitro. Finally, the rHyr1p-N vaccine was protective against non-albicansCandida spp.Thesepreclinicaldata demonstratethatrHyr1p-N is likelytobeanovel targetfor developing bothactiveandpassiveimmunizationstrategiesagainstCandidainfections. Citation: Luo G, Ibrahim AS, French SW, Edwards JE Jr, Fu Y (2011) Active and Passive Immunization with rHyr1p-N Protects Mice against Hematogenously DisseminatedCandidiasis.PLoSONE6(10):e25909.doi:10.1371/journal.pone.0025909 Editor:MartaFeldmesser,AlbertEinsteinCollegeofMed