Adult-Age Inflammatory Pain Experience Enhances Long-Term Pain Vigilance in Rats 英文参考文献.docVIP

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Adult-Age Inflammatory Pain Experience Enhances Long-Term Pain Vigilance in Rats 英文参考文献.doc

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Adult-Age Inflammatory Pain Experience Enhances Long-Term Pain Vigilance in Rats 英文参考文献

Adult-AgeInflammatoryPainExperienceEnhancesLong- TermPainVigilanceinRats Sheng-GuangLi1,2,Jin-YanWang1*,FeiLuo1* 1KeyLaboratoryofMentalHealth,InstituteofPsychology,ChineseAcademyofSciences,Beijing,China,2TheGraduateUniversity,ChineseAcademyofSciences,Beijing, China Abstract Background:Previousanimalstudieshaveillustratedamodulatoryeffectofneonatalpainexperienceonsubsequentpain- relatedbehaviors.However,therelationshipbetweenchronicpainstatusinadulthoodandfuturepainperceptionremains unclear. Methodology/Principal Findings: In the current study, we investigated the effects of inflammatory pain experience on subsequentformalin-evokedpainbehaviorsandfearconditioninginducedbynoxiousstimulationinadultrats.Ourresults demonstratedanincreaseofthesecondbutnotthefirstphaseofformalin-inducedpainbehaviorsinanimalswithahistory ofinflammatorypainthathaverecovered.Similarly,ratswithpersistentpainexperiencedisplayedfacilitatedacquisitionand prolonged retention of pain-related conditioning. These effects of prior pain experience on subsequent behavior were preventedbyrepeatedmorphineadministrationatanearlystageofinflammatorypain. Conclusions/Significance:Theseresultssuggestthatchronicpaindiseases,ifnotproperlyandpromptlytreated,mayhave a long-lasting impact on processing and perception of environmental threats. This may increase the susceptibility of patients to subsequent pain-related disorders, even when chronic pain develops in adulthood. These data highlight the importanceoftreatmentofchronicpainatanearlystage. Citation:LiS-G,WangJ-Y,LuoF(2012)Adult-AgeInflammatoryPainExperienceEnhancesLong-TermPainVigilanceinRats.PLoSONE7(5):e36767.doi:10.1371/ journal.pone.0036767 Editor:AlessioAvenanti,UniversityofBologna,Italy ReceivedNovember22,2011;AcceptedApril12,2012;PublishedMay4,2012 Copyright:?2012Lietal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalautho