Affective Responses by Adults with Autism Are Reduced to Social Images but Elevated to Images Related to Circumscribed Interests 英文参考文献.docVIP

AffectiveResponsesbyAdultswithAutismAreReduced toSocialImagesbutElevatedtoImagesRelatedto CircumscribedInterests NoahJ.Sasson1*.,GabrielS.Dichter2.,JamesW.Bodfish2 1SchoolofBehavioralandBrainSciences,TheUniversityofTexasatDallas,Richardson,Texas,UnitedStatesofAmerica,2CarolinaInstituteforDevelopmentalDisabilities, SchoolofMedicine,UniversityofNorthCarolinaatChapelHill,ChapelHill,NorthCarolina,UnitedStatesofAmerica Abstract Individualswithautismspectrumdisorders(ASD)demonstrateincreasedvisualattentionandelevatedbrainrewardcircuitry responses to images related to circumscribed interests (CI), suggesting that a heightened affective response to CI may underlietheirdisproportionatesalienceandrewardvalueinASD.TodetermineifindividualswithASDdifferfromtypically developing (TD) adults in their subjective emotional experience of CI object images, non-CI object images and social images, 213 TD adults and 56 adults with ASD provided arousal ratings (sensation of being energized varying along a dimensionfromcalmtoexcited)andvalenceratings(emotionalityvaryingalongdimensionofapproachtowithdrawal)for aseriesof114imagesderivedfrompreviousresearchonCI.Thegroupsdidnotdifferonarousalratingsforanyimagetype, butASDadultsprovidedhighervalenceratingsthanTDadultsforCI-relatedimages,andlowervalenceratingsforsocial images.Evenafterco-varyingtheeffectsofsex,theASDgroup,butnottheTDgroup,gavehighervalenceratingstoCI imagesthansocialimages.ThesefindingsprovideadditionalevidencethatASDischaracterizedbyapreferenceforcertain categoriesofnon-socialobjectsandareducedpreferenceforsocialstimuli,andsupportthedisseminationofthisimageset forexaminingaspectsofthecircumscribedinterestphenotypeinASD. Citation:SassonNJ,DichterGS,BodfishJW(2012)AffectiveResponsesbyAdultswithAutismAreReducedtoSocialImagesbutElevatedtoImagesRelatedto CircumscribedInterests.PLoSONE7(8):e42457.doi:10.1371/journal.pone.0042457 Editor:FrankKrueger,GeorgeMasonUniversity/KrasnowInstituteforAdvancedStudy,UnitedStatesofAmerica ReceivedFe