Agreement of Blood Spot Card Measurements of Vitamin D Levels with Serum, Whole Blood Specimen Types and a Dietary Recall Instrument 英文参考文献.docVIP

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Agreement of Blood Spot Card Measurements of Vitamin D Levels with Serum, Whole Blood Specimen Types and a Dietary Recall Instrument 英文参考文献.doc

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Agreement of Blood Spot Card Measurements of Vitamin D Levels with Serum, Whole Blood Specimen Types and a Dietary Recall Instrument 英文参考文献

AgreementofBloodSpotCardMeasurementsofVitamin DLevelswithSerum,WholeBloodSpecimenTypesanda DietaryRecallInstrument EmmaK.Larkin1*,TebebGebretsadik2,NathanKoestner1,MarkS.Newman3,ZhouwenLiu2,KeciaN. Carroll4,PatriciaMinton1,KimWoodward1,TinaV.Hartert1 1Division of Allergy, Pulmonary and Critical Care, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America, 2Department of Biostatistics, Vanderbilt University, Nashville, Tennessee, United States of America, 3ZRT Laboratory, Beaverton, Oregon, United States of America, 4Department of Pediatrics,VanderbiltUniversity,Nashville,Tennessee,UnitedStatesofAmerica Abstract Background: The ability to measure 25-hydroxyvitamin D (25OHD) levels from blood spot cards can simplify sample collectionversussamplesobtainedbyvenipuncture,particularlyinpopulationsinwhomitisdifficulttodrawblood.We sought to validate the use of blood spot samples for the measurement of 25OHD compared to serum or whole blood samplesandcorrelatethemeasuredlevelswithintakeestimatedfromdietaryrecall. Methods:Utilizing109biologicalmothersofinfantsenrolledintheTennesseeChildren’sRespiratoryInitiativecohort,we measured 25OHD levels through highly selective liquid chromatography–tandem mass spectrometry on samples from blood spot cards, serum, and whole blood collected at enrollment. Dietary questionnaires (n=65) were used to assess 25OHDintakebydietaryrecall.Samplecollectionmeasureswereassessedforagreementand25OHDlevelsforassociation withdietary25OHDintake. Results:Themeanabsolutedifferences(95%CI)in25OHDlevelsmeasuredbetweenwholebloodandbloodspot(n=50 pairs)orserumandbloodspot(n=20)were3.2(95%CI:1.6,4.8)ng/mland1.5(95%CI:20.5,3.4)ng/mL.Intakebydietary recallwasmarginallyassociatedwith25OHDlevelsafteradjustmentforcurrentsmokingandraceinlinearregression. Discussion:25OHDlevelsdeterminedbymassspectrometryfrombloodspotcards,serumandwholebloodshowrelatively goodagreement,although25OHDlevelsareslightlylowerwhenmeasuredbybloodspo