Altered Ratio of IFN-γIL-10 in Patients with Drug Resistant Mycobacterium tuberculosis and HIV- Tuberculosis Immune Reconstitution Inflammatory Syndrome 英文参考文献.docVIP

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Altered Ratio of IFN-γIL-10 in Patients with Drug Resistant Mycobacterium tuberculosis and HIV- Tuberculosis Immune Reconstitution Inflammatory Syndrome 英文参考文献.doc

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Altered Ratio of IFN-γIL-10 in Patients with Drug Resistant Mycobacterium tuberculosis and HIV- Tuberculosis Immune Reconstitution Inflammatory Syndrome 英文参考文献

AlteredRatioofIFN-c/IL-10inPatientswithDrug ResistantMycobacteriumtuberculosisandHIV- TuberculosisImmuneReconstitutionInflammatory Syndrome KeiraH.Skolimowska1,3,MolebogengX.Rangaka1,GraemeMeintjes1,3,4,DominiqueJ.Pepper4, RonnettSeldon1,KerrynMatthews1,RobertJ.Wilkinson1,2,3,4,KatalinA.Wilkinson1,2 * 1Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa, 2MRC NationalInstituteforMedicalResearch,London,UnitedKingdom,3DivisionofMedicine,ImperialCollegeLondon,London,UnitedKingdom,4InfectiousDiseasesUnit, GFJoosteHospital,CapeTown,SouthAfrica Abstract WehavedescribedaclinicalrelationshipbetweenHIV-TuberculosisImmuneReconstitutionInflammatorySyndrome(TB- IRIS) and anti-tubercular drug resistance. Here we studied the immune response of TB-IRIS patients from whom a drug- resistant(n=11)ordrug-susceptible(n=25)Mycobacteriumtuberculosis(MTB)strainwasisolatedafterpresentingwithTB- IRIS.ELISpotanalysisandmultiplexcytokineanalysisofthesupernatantcollectedfromperipheralbloodmononuclearcells stimulated overnight with the heat-killed H37Rv MTB laboratory strain was used. Although there was no statistical differenceinIFN-gammaELISpotresponsesbetweenthetwogroups,theresultspointtowardshigherbacterialloadinthe drug-resistant patients, possibly due to failed therapy. The ratio between secreted IFN-gamma/IL-10 and IL-2/IL-10 was significantlylowerinTB-IRISpatientsinwhomthecauseofTBwasadrug-resistantstraincomparedtothosewithafully sensitive strain (p=0.02). Since host immune responses are dependent on the bacterial load, we hypothesise that the impairedcytokinebalanceislikelytobecausedbythepoorlycontrolledbacterialgrowthinthesepatients. Citation:SkolimowskaKH,RangakaMX,MeintjesG,PepperDJ,SeldonR,etal.(2012)AlteredRatioofIFN-c/IL-10inPatientswithDrugResistantMycobacterium tuberculosisandHIV-TuberculosisImmuneReconstitutionInflammatorySyndrome.PLoSONE7(10):e46481.doi:10.1371/journal.po