Altered Spontaneous Activity in Anisometropic Amblyopia Subjects Revealed by Resting-State fMRI 英文参考文献.docVIP

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Altered Spontaneous Activity in Anisometropic Amblyopia Subjects Revealed by Resting-State fMRI 英文参考文献.doc

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Altered Spontaneous Activity in Anisometropic Amblyopia Subjects Revealed by Resting-State fMRI 英文参考文献

AlteredSpontaneousActivityinAnisometropic AmblyopiaSubjects:RevealedbyResting-StatefMRI XiaomingLin1*,KunDing1,YongLiu2*,XiaoheYan1,ShaojieSong1,TianziJiang2,3,4* 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China, 2LIAMA Center for Computational Medicine, NationalLaboratoryofPatternRecognition,InstituteofAutomation,TheChineseAcademyofSciences,Beijing,China,3KeyLaboratoryforNeuroInformationofMinistry ofEducation,SchoolofLifeScienceandTechnology,UniversityofElectronicScienceandTechnologyofChina,Chengdu,China,4TheQueenslandBrainInstitute,The UniversityofQueensland,Brisbane,Queensland,Australia Abstract Amblyopia, also known as lazy eye, usually occurs during early childhood and results in poor or blurred vision. Recent neuroimagingstudieshavefoundcorticalstructural/functionalabnormalitiesinamblyopia.However,untilnow,itwasstill not knownwhether the spontaneous activity of the brain changes in amblyopia subjects. Inthe present study, regional homogeneity(ReHo),ameasureofthehomogeneityoffunctionalmagneticresonanceimagingsignals,wasusedforthe first time to investigate changes in resting-state local spontaneous brain activity in individuals with anisometropic amblyopia.Comparedwithage-andgender-matchedsubjectswithnormalvision,theanisometropicamblyopiasubjects showed decreased ReHo of spontaneous brain activity in the right precuneus, the left medial prefrontal cortex, the left inferiorfrontalgyrus,andtheleftcerebellum,andincreasedReHoofspontaneousbrainactivitywasfoundinthebilateral conjunctionareaofthepostcentralandprecentralgyri,theleftparacentrallobule,theleftsuperiortemporalgyrus,theleft fusiform gyrus, the conjunction area of the right insula, putamen and the right middle occipital gyrus. The observed decreasesinReHomayreflectdecreasedvisuo-motorprocessingability,andtheincreasesinReHointhesomatosensory cortices,themotorareasandtheauditoryareamayindicatecompensatoryplasticityinamblyopia. Citation:LinX,DingK,Li