An Antimicrobial Peptide Regulates Tumor-Associated Macrophage Trafficking via the Chemokine Receptor CCR2, a Model for Tumorigenesis 英文参考文献.docVIP

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An Antimicrobial Peptide Regulates Tumor-Associated Macrophage Trafficking via the Chemokine Receptor CCR2, a Model for Tumorigenesis 英文参考文献.doc

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An Antimicrobial Peptide Regulates Tumor-Associated Macrophage Trafficking via the Chemokine Receptor CCR2, a Model for Tumorigenesis 英文参考文献

AnAntimicrobialPeptideRegulatesTumor-Associated MacrophageTraffickingviatheChemokineReceptor CCR2,aModelforTumorigenesis GeJin1,5*,HameemI.Kawsar1,StanleyA.Hirsch2,ChunZeng3,XunJia1,ZhiminFeng1,SantoshK. Ghosh1,QingYinZheng4,5,AiminZhou3,ThomasM.McIntyre6,AaronWeinberg1 1Department of Biological Sciences, Case Western Reserve University School of Dental Medicine, Cleveland, Ohio, United States of America, 2Department of Oral Pathology,CaseWesternReserveUniversitySchoolofDentalMedicine,Cleveland,Ohio,UnitedStatesofAmerica,3DepartmentofChemistry,ClevelandStateUniversity, Cleveland,Ohio,UnitedStatesofAmerica,4DepartmentofOtolaryngology-HeadandNeckSurgery,UniversityHospitalsofCleveland,CaseWesternReserveUniversity SchoolofMedicine,Cleveland,Ohio,UnitedStatesofAmerica,5CaseComprehensiveCancerCenter,Cleveland,Ohio,UnitedStatesofAmerica,6DepartmentofCell Biology,LernerResearchInstitute,ClevelandClinicCollegeofMedicineofCaseWesternReserveUniversity,Cleveland,Ohio,UnitedStatesofAmerica Abstract Background:Tumor-associatedmacrophages(TAMs)constituteasignificantpartofinfiltratinginflammatorycellsthatare frequentlycorrelatedwithprogressionandpoorprognosisofavarietyofcancers.Tumorcell-producedhumanb-defensin-3 (hBD-3)hasbeenassociatedwithTAMtraffickinginoralcancer;however,itsinvolvementintumor-relatedinflammatory processesremainslargelyunknown. Methodology: The relationship between hBD-3, monocyte chemoattractant protein-1 (MCP-1), TAMs, and CCR2 was examinedusingimmunofluorescencemicroscopyinnormalandoralcarcinomainsitubiopsyspecimens.TheabilityofhBD- 3tochemoattracthostmacrophagesinvivousinganudemousemodelandanalysisofhBD-3onmonocyticcellmigration invitro,applyingacross-desensitizationstrategyofCCR2anditspharmacologicalinhibitor(RS102895),respectively, was alsocarriedout. Conclusions/Findings:MCP-1,themostfrequentlyexpressedtumorcell-associatedchemokine,wasnotproducedbytumor cellsnorcorrelatedwiththerecruitmentofmacrophagesinoralcarcinomainsitulesions.However,hBD-3was