An Autopsy Study Describing Causes of Death and Comparing Clinico-Pathological Findings among Hospitalized Patients in Kampala, Uganda 英文参考文献.docVIP

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An Autopsy Study Describing Causes of Death and Comparing Clinico-Pathological Findings among Hospitalized Patients in Kampala, Uganda 英文参考文献.doc

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An Autopsy Study Describing Causes of Death and Comparing Clinico-Pathological Findings among Hospitalized Patients in Kampala, Uganda 英文参考文献

AnAutopsyStudyDescribingCausesofDeathand ComparingClinico-PathologicalFindingsamong HospitalizedPatientsinKampala,Uganda JannekeA.Cox1*.,RobertL.Lukande2.,AnnM.Nelson3,HarrietMayanja-Kizza4 ,Robert Colebunders1,5,EricVanMarck5,YukariC.Manabe6,7 1DepartmentofClinicalSciences,InstituteofTropicalMedicine,Antwerp,Belgium,2DepartmentofPathology,MakerereUniversity,Kampala,Uganda,3JointPathology Center,SilverSpring,Maryland,UnitedStatesofAmerica,4DepartmentofInternalMedicine,MakerereUniversity,Kampala,Uganda,5FacultyofMedicine,Universityof Antwerp, Antwerp, Belgium, 6Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda, 7Division of Infectious Diseases, DepartmentofMedicine,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,Maryland,UnitedStatesofAmerica Abstract Background: Information on causes of death in HIV-infected patients in Sub-Saharan Africa is mainly derived from observationalcohortandverbalautopsystudies.Autopsyisthegoldstandardtoascertaincauseofdeath.Weconductedan autopsystudytodescribeandcomparetheclinicalandautopsycausesofdeathandcontributoryfindingsinhospitalized HIV-infectedandHIV-uninfectedpatientsinUganda. Methods: Between May and September 2009 a complete autopsy was performed on patients that died on a combined infectious diseases gastroenterology ward in Mulago Hospital in Kampala, Uganda. Autopsy cause of death and contributingfindingswerebasedonthemacro-andmicroscopicpost-mortemfindingscombinedwithclinicalinformation. Clinical diagnoses were reported by the ward doctor and classified as confirmed, highly suspected, considered or not considered,basedoninformationderivedfromthemedicalchart.ResultsarereportedaccordingtoHIVserostatus. Results:Fifty-threecompleteautopsieswereperformedin66%HIV-positive,21%HIV-negativeand13%patientswithan unknownHIVserologicalstatus.Infectiousdiseasescauseddeathin83%ofHIV-positivepatients,withdisseminatedTBas themaindiagnosiscausing37%ofdeaths.Thespectrumofillnessandcausesofdeathwe