An HR-MAS MR Metabolomics Study on Breast Tissues Obtained with Core Needle Biopsy 英文参考文献.docVIP

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An HR-MAS MR Metabolomics Study on Breast Tissues Obtained with Core Needle Biopsy 英文参考文献.doc

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An HR-MAS MR Metabolomics Study on Breast Tissues Obtained with Core Needle Biopsy 英文参考文献

AnHR-MASMRMetabolomicsStudyonBreastTissues ObtainedwithCoreNeedleBiopsy MuLanLi1.,YonghyunSong2.,NariyaCho1,JungMinChang1,HyeRyoungKoo1,AnnYi1 ,Hyeonjin Kim1,SunghyoukPark2*,WooKyungMoon1* 1Department ofRadiology,CollegeofMedicine,SeoulNationalUniversity, Jongno-gu,Seoul,Korea, 2Department ofBiochemistryandCenterforAdvancedMedical Education,CollegeofMedicine,InhaUniversity,Chung-gu,Incheon,Korea Abstract Background:Muchresearchhasbeendevotedtothedevelopmentofnewbreastcancerdiagnosticmeasures,including those involving high-resolution magic angle spinning (HR-MAS) magnetic resonance (MR) spectroscopic techniques. PreviousHR-MASMRresultshavebeenobtainedfrompost-surgerysamples,whichlimitstheirdirectclinicalapplicability. Methodology/PrincipalFindings:Inthepresentstudy,weperformedHR-MASMRspectroscopicstudieson31breasttissue samples(13cancerand18non-cancer)obtainedbypercutaneouscoreneedlebiopsy.Weshowedthatcancerandnon- cancersamplescanbediscriminatedverywellwithOrthogonalProjectionstoLatentStructure-DiscriminantAnalysis(OPLS- DA) multivariate model on the MR spectra. A subsequent blind test showed 69% sensitivity and 94% specificity in the predictionofthecancerstatus.Aspectralanalysisshowedthatincancercells,taurine-andcholine-containingcompounds areelevated.Ourapproach,additionally,couldpredicttheprogesteronereceptorstatusesofthecancerpatients. Conclusions/Significance:HR-MASMRmetabolomicsonintactbreasttissuesobtainedbycoreneedlebiopsymayhavea potentialtobeusedasacomplementtothecurrentdiagnosticandprognosticmeasuresforbreastcancers. Citation:LiM,SongY,ChoN,ChangJM,KooHR,etal.(2011)AnHR-MASMRMetabolomicsStudyonBreastTissuesObtainedwithCoreNeedleBiopsy.PLoS ONE6(10):e25563.doi:10.1371/journal.pone.0025563 Editor:DanielMonleon,InstitutodeInvestigacio′nSanitariaINCLIVA,Spain ReceivedMay26,2011;AcceptedSeptember6,2011;PublishedOctober18,2011 Copyright:?2011Lietal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestr