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Androstenol – a Steroid Derived Odor Activates the Hypothalamus in Women 英文参考文献
Androstenol–aSteroidDerivedOdorActivatesthe
HypothalamusinWomen
IvankaSavic1*,HansBerglund2
1Stockholm Brain Institute, Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden, 2Department of Medicine, Karolinska University Hospital,
Stockholm,Sweden
Abstract
Background:Whetherpheromonesignalingexistsinhumansisstillamatterofintensediscussion.Inthepresentstudywe
testedifsmellingofAndrostenol,asteroidproducedbythehumanbodyandreportedtoaffecthumanbehavior,mayelicit
cerebral activation. A further issue was to evaluate whether the pattern of activation resembles the pattern of common
odors.
Methodology:PETmeasurementsofregionalcerebralbloodflow(rCBF)wereconductedin16healthyheterosexualwomen
duringpassivesmellingofAndrostenol,fourordinaryodors(OO),andodorlessair(thebaselinecondition).
Principalfindings:SmellingAndrostenolcausedactivationofaportionofthehypothalamus,whichaccordingtoanimal
datamediatesthepheromonetriggeredmatingbehavior.SmellingofOO,ontheotherhand,engagedonlytheclassical
olfactoryregions(thepiriformcortex,lateralamygdala,anteriorinsularandanteriorcingulatecortex).
Conclusions:Theobservedpatternofactivationisverysimilartothepatternpreviouslydetectedwith4,16-androstadien-3-
oneinheterosexualfemales.Itsuggeststhatseveralcompoundsreleasedbyhumanbodymayactivatecerebralnetworks
involvedinhumanreproduction.
Citation: Savic I, Berglund H (2010) Androstenol – a Steroid Derived Odor Activates the Hypothalamus in Women. PLoS ONE 5(2): e8651. doi:10.1371/
journal.pone.0008651
Editor:HiroakiMatsunami,DukeUniversity,UnitedStatesofAmerica
ReceivedAugust17,2009;AcceptedDecember9,2009;PublishedFebruary17,2010
Copyright: ? 2010 Savic, Berglund. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:ThisstudywasfundedbytheOsherProSueciaFoundationandSwedishResearchCouncil.Thefundersh
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