Analysis of Transposon Interruptions Suggests Selection for L1 Elements on the X Chromosome 英文参考文献.docVIP
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Analysis of Transposon Interruptions Suggests Selection for L1 Elements on the X Chromosome 英文参考文献
AnalysisofTransposonInterruptionsSuggestsSelection
forL1ElementsontheXChromosome
Gyo¨rgyAbrusa′n1,2¤*,JotiGiordano1,PeterE.Warburton1
1DepartmentofGeneticsandGenomicSciences,MountSinaiSchoolofMedicineofNewYorkUniversity,IcahnMedicalInstitute,NewYork,NewYork,UnitedStatesof
America,2LaboratoryofAquaticEcologyandEvolution,DepartmentofBiology,UniversityofLeuven,Leuven,Belgium
Abstract
IthasbeenhypothesisedthatthemassiveaccumulationofL1transposableelementsontheXchromosomeisduetotheir
function in X inactivation, and that the accumulation of Alu elements near genes is adaptive. We tested the possible
selective advantage of these two transposable element (TE) families with a novel method, interruption analysis. In
mammaliangenomes,alargenumberofTEsinterruptotherTEsduetothehighoverallabundanceandageofrepeats,and
theseinterruptionscanbeusedtotestwhetherTEsareselectivelyneutral.InterruptionsofTEs,whicharebeneficialforthe
host,areexpectedtobedeleteriousandunderrepresentedcomparedwithneutralones.WefoundthatL1elementsinthe
regionsoftheXchromosomethatcontainthemajorityoftheinactivatedgenesaresignificantlylessfrequentlyinterrupted
thanontheautosomes,whileL1sneargenesthatescapeinactivationareinterruptedwithhigherfrequency,supportingthe
hypothesisthatL1sontheXchromosomeplayaroleinitsinactivation.Inaddition,weshowthatTEsarelessfrequently
interrupted in introns than in intergenic regions, probably due to selection against the expansion of introns, but the
insertionpatternofAlusiscomparabletootherrepeats.
Citation: Abrusa′n G,GiordanoJ,WarburtonPE(2008)AnalysisofTransposonInterruptionsSuggests SelectionforL1ElementsontheXChromosome.PLoS
Genet4(8):e1000172.doi:10.1371/journal.pgen.1000172
Editor:DmitriA.Petrov,StanfordUniversity,UnitedStatesofAmerica
ReceivedFebruary26,2008;AcceptedJuly17,2008;PublishedAugust29,2008
Copyright: ? 2008 Abrusa′n et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse
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