Angiotensin-Converting Enzyme InsertionDeletion Polymorphism Contributes to Ischemic Stroke Risk A Meta-Analysis of 50 Case-Control Studies 英文参考文献.docVIP
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Angiotensin-Converting Enzyme InsertionDeletion Polymorphism Contributes to Ischemic Stroke Risk A Meta-Analysis of 50 Case-Control Studies 英文参考文献
Angiotensin-ConvertingEnzymeInsertion/Deletion
PolymorphismContributestoIschemicStrokeRisk:A
Meta-Analysisof50Case-ControlStudies
ZhizhongZhang.,GelinXu.,DezhiLiu.,XinyingFan,WushengZhu,XinfengLiu*
DepartmentofNeurology,JinlingHospital,NanjingUniversitySchoolofMedicine,JiangsuProvince,China
Abstract
Background: Many studies have investigated the association between the angiotensin-converting enzyme (ACE ) gene
insertion/deletion (I/D) polymorphism and risk of ischemic stroke. However, the evidence is inadequate to draw robust
conclusions because most studies were generally small and conducted in heterogeneous populations. To shed light on
theseinconclusivefindings,weconductedalargemeta-analysisofstudiesrelatingtheACEI/Dpolymorphismtotheriskof
ischemicstroke.
Methods:RelevantstudieswereidentifiedbysearchingPubMedandEmbasethroughFebruary2012andbyreviewingthe
referencesofretrievedarticles.Weincludedstudiesthatreportedoddsratio(OR)with95%confidenceinterval(CI)forthe
associationbetweenthispolymorphismandischemicstrokerisk.
Results:Fiftyindependentpublications,with10070strokecasesand22103controls,wereincluded.Theresultsindicated
thattheDDhomozygotecarriershada37%higherriskofischemicstrokewhencomparedwiththehomozygotesIIand
heterozygote ID [odds ratio (OR)=1.37, 95% confidence interval (CI): 1.22–1.53]. Subgroup analyses indicated that this
higher risk was more pronounced among Asians, hospital-based studies, and small vessel disease (SVD). Potential
publication bias may exist, but correction for this bias using a formal statistical method did not materially alter the
combinedriskestimate.
Conclusion: The results of our meta-analysis indicate that the D allele of ACE I/D polymorphism is a low-penetrance
susceptibilitymarkerofischemicstroke.
Citation:ZhangZ,XuG,LiuD,FanX,ZhuW,etal.(2012)Angiotensin-ConvertingEnzymeInsertion/DeletionPolymorphismContributestoIschemicStrokeRisk:
AMeta-Analysisof50Case-ControlStudies.PLoSONE7(10):e46495.doi:10.1371/journal.pone.0046495
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