Antibiotics Increase Gut Metabolism and Antioxidant Proteins and Decrease Acute Phase Response and Necrotizing Enterocolitis in Preterm Neonates 英文参考文献.docVIP
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Antibiotics Increase Gut Metabolism and Antioxidant Proteins and Decrease Acute Phase Response and Necrotizing Enterocolitis in Preterm Neonates 英文参考文献
AntibioticsIncreaseGutMetabolismandAntioxidant
ProteinsandDecreaseAcutePhaseResponseand
NecrotizingEnterocolitisinPretermNeonates
PingpingJiang1,3,MichaelLadegaardJensen3,MaleneSkovstedCilieborg3,ThomasThymann3 ,Jennifer
Man-FanWan1,Wai-HungSit1,GeorgeL.Tipoe2,PerTorpSangild3*
1SchoolofBiologicalSciences,TheUniversityofHongKong,HongKong,People’sRepublicofChina,2DepartmentofAnatomy,TheUniversityofHongKong,Hong
Kong,People’sRepublicofChina,3DepartmentofHumanNutrition,UniversityofCopenhagen,Frederiksberg,Denmark
Abstract
Background: The appropriate useof antibiotics for preterm infants, which are highly susceptible to developnecrotizing
enterocolitis(NEC),isnotclear.WhileantibiotictherapyiscommonlyusedinneonateswithNECsymptomsandsepsis,it
remains unknown how antibiotics may affect the intestine and NEC sensitivity. We hypothesized that broad-spectrum
antibiotics, given immediately after preterm birth, would reduce NEC sensitivity and support intestinal protective
mechanisms.
Methodology/Principal Findings: Preterm pigs were treated with antibiotics for 5 d (oral and systemic doses of
gentamycin,ampicillinandmetrodinazole;ABgroup)andcomparedwithuntreatedpigs.Onlytheuntreatedpigsshowed
evidenceofNEClesionsandreduceddigestivefunction,asindicatedbyloweredvillusheightandactivityofbrushborder
enzymes. In addition, 53 intestinal and 22 plasma proteins differed in expression between AB and untreated pigs. AB
treatmentincreasedtheabundanceofintestinalproteinsrelatedtocarbohydrateandproteinmetabolism,actinfilaments,
ironhomeostasisandantioxidants.Further,heatshockproteinsandthecomplementsystemwereaffectedsuggestingthat
all these proteins were involved in the colonization-dependent early onset of NEC. In plasma, acute phase proteins
(haptoglobin,complementproteins)decreased,whilealbumin,cleavedC3,ficolinandtransferrinincreased.
Conclusions/Significance:DepressedbacterialcolonizationfollowingABtreatmentincreasesmucosalintegrityandreduces
bacteria-associated inflammatory response
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