ANS Aberrant Neurodevelopment of the Social Cognition Network in Adolescents with Autism Spectrum Disorders 英文参考文献.docVIP
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ANS Aberrant Neurodevelopment of the Social Cognition Network in Adolescents with Autism Spectrum Disorders 英文参考文献
ANS:AberrantNeurodevelopmentoftheSocial
CognitionNetworkinAdolescentswithAutismSpectrum
Disorders
YaweiCheng1,2,Kun-HsienChou1,Yang-TengFan1,Ching-PoLin1*
1InstituteofNeuroscience,NationalYang-MingUniversity,Taipei,Taiwan,2DepartmentofPhysicalMedicineandRehabilitation,NationalYang-MingUniversityHospital,
Yilan,Taiwan
Abstract
Background:Autismspectrumdisorders(ASD)arecharacterizedbyaberrantneurodevelopment.AlthoughtheASDbrain
undergoes precocious growth followed by decelerated maturation during early postnatal period of childhood, the
neuroimagingapproachhasnotbeenempiricallyappliedtoinvestigatehowtheASDbraindevelopsduringadolescence.
Methodology/PrincipalFindings:Weenrolled25maleadolescentswithhighfunctioningASDand25typicallydeveloping
controlsforvoxel-basedmorphometricanalysisofstructuralmagneticresonanceimage.Resultsindicatethatthereisan
imbalanceofregionalgraymattervolumesandconcentrationsalongwithnoglobalbrainenlargementinadolescentswith
high functioning ASD relative to controls. Notably, the right inferior parietal lobule, a role in social cognition, have a
significantinteractionofagebygroupsasindicatedbyabsenceofanage-relatedgainofregionalgraymattervolumeand
concentrationforneurodevelopmentalmaturationduringadolescence.
Conclusions/Significance: Thefindingsindicatetheneuralcorrelatesofsocialcognitionexhibitsaberrantneurodevelop-
mentduringadolescenceinASD,whichmaycastsomelightonthebraingrowthdysregulationhypothesis.Theperiodof
abnormal brain growth during adolescence may be characteristic of ASD. Age effects must be taken into account while
measuresofstructuralneuroimaginghavebeenclinicallyputforwardaspotentialphenotypesforASD.
Citation:ChengY,ChouK-H,FanY-T,LinC-P(2011)ANS:AberrantNeurodevelopmentoftheSocialCognitionNetworkinAdolescentswithAutismSpectrum
Disorders.PLoSONE6(4):e18905.doi:10.1371/journal.pone.0018905
Editor:ThomasBurne,UniversityofQueensland,Australia
ReceivedAugust1,2010;AcceptedMarch23,2011;PublishedApril26,2011
Copyright: ? 2011 Cheng et
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