Assessment of the Association of Matrix Metalloproteinases with Myopia, Refractive Error and Ocular Biometric Measures in an Australian Cohort 英文参考文献.docVIP
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Assessment of the Association of Matrix Metalloproteinases with Myopia, Refractive Error and Ocular Biometric Measures in an Australian Cohort 英文参考文献
AssessmentoftheAssociationofMatrix
MetalloproteinaseswithMyopia,RefractiveErrorand
OcularBiometricMeasuresinanAustralianCohort
MariaSchache*,PaulN.Baird
CentreforEyeResearchAustralia,UniversityofMelbourne,RoyalVictorianEyeandEarHospital,Melbourne,Australia
Abstract
Extracellular matrix proteins have been implicated in protein remodelling of the sclera in refractive error. The matrix
metalloproteinases(MMPs)fallingintothecollagenase(MMP1,MMP8,MMP13),gelatinase(MMP2,MMP9)andstromelysin
(MMP3,MMP10,MMP11)functionalgroupsareparticularlyimportant.Wewishedtoassesstheirassociationwithmyopia,
refractive error and ocular biometric measures in an Australian cohort. A total of 543 unrelated individuals of Caucasian
ethnicity were genotyped including 269 myopes (#21.0D) and 274 controls (.21.0D). Tag single nucleotide
polymorphisms (SNPs) (n=53) were chosen to encompass these eight MMPs. Association tests were performed using
linearandlogisticregressionanalysiswithageandgenderascovariates.Sphericalequivalent,myopia,axiallength,anterior
chamberdepthandcornealcurvaturewerethephenotypesofinterest.Initialfindingsindicatedthatthebestpvaluesfor
eachtraitwere0.02formyopiaatrs2274755(MMP9),0.02forSEatbothrs3740938(MMP8)andrs131451(MMP11),0.01for
axial length at r(MMP8), 0.01 for anterior chamber depth at rs498186 (MMP1) and 0.02 at rs10488 (MMP1).
However,followingcorrectionformultipletesting,noneoftheseSNPsremainedstatisticallysignificant.Ourdatasuggests
that the MMPs in the collagenase, gelatinase and stromelysin categories do not appear to be associated with myopia,
refractiveerrororocularbiometricmeasuresinthiscohort.
Citation:SchacheM,BairdPN(2012)AssessmentoftheAssociationofMatrixMetalloproteinaseswithMyopia,RefractiveErrorandOcularBiometricMeasuresin
anAustralianCohort.PLoSONE7(10):e47181.doi:10.1371/journal.pone.0047181
Editor:AndreasOhlmann,UniversityofRegensburg,Germany
ReceivedMay28,2012;AcceptedSeptember10,2012;PublishedOctober15,2012
Copyright: ? 2012 Scha¨ch
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