Association between the Perioperative Antioxidative Ability of Platelets and Early Post-Transplant Function of Kidney Allografts A Pilot Study 英文参考文献.docVIP

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Association between the Perioperative Antioxidative Ability of Platelets and Early Post-Transplant Function of Kidney Allografts A Pilot Study 英文参考文献.doc

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Association between the Perioperative Antioxidative Ability of Platelets and Early Post-Transplant Function of Kidney Allografts A Pilot Study 英文参考文献

AssociationbetweenthePerioperativeAntioxidative AbilityofPlateletsandEarlyPost-TransplantFunctionof KidneyAllografts:APilotStudy BarbaraDo?e?gowska1.,WojciechB?ogowski1*.,LeszekDoman′ski2 1Department ofLaboratory Diagnostics andMolecular Medicine,PomeranianMedicalUniversity, Szczecin,Poland, 2Department ofNephrology, Transplantationand InternalMedicine,PomeranianMedicalUniversity,Szczecin,Poland Abstract Background: Recent studies have demonstrated that the actions of platelets may unfavorably influence post-transplant function of organ allografts. In this study, the association between post-transplant graft function and the perioperative activityofplateletantioxidantswasexaminedamongkidneyrecipientsdividedintoearly(EGF),slow(SGF),anddelayed graftfunction(DGF)groups. Methodology/Principal Findings: Activities of superoxide dismutase, catalase, glutathione transferase (GST), glutathione peroxidase, and glucose-6-phosphate dehydrogenase (G6P) were determined and levels of glutathione, oxidized glutathione, and isoprostane were measured in blood samples collected immediately before and during the first and fifthminutesofrenalallograftreperfusion.Ourresultsdemonstratedasignificantincreaseinisoprostanelevelsinallgroups. Interestingly,inDGFpatients,significantlylowerlevelsofperioperativeactivityofcatalase(p,0.02)andGST(p,0.02)were observed. Moreover, in our study, the activity of platelet antioxidants was associated with intensity of perioperative oxidativestress.FordiscriminatingSGF/DGFfromEGF,sensitivity,specificity,andpositiveandnegativepredictivevaluesof plateletantioxidantswere81–91%,50–58%,32–37%,and90–90.5%,respectively. Conclusions:Duringrenaltransplantation,significantchangesoccurintheactivityofplateletantioxidants.Thesechanges seemtobeassociatedwithpost-transplantgraftfunctionandcanbepotentiallyusedtodifferentiatebetweenEGFand SGF/DGF. To the best of our knowledge, this is the first study to reveal the potential protective role of platelets in the humantrans