Association of Common Genetic Variants in the MAP4K4 Locus with Prediabetic Traits in Humans 英文参考文献.docVIP
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Association of Common Genetic Variants in the MAP4K4 Locus with Prediabetic Traits in Humans 英文参考文献
AssociationofCommonGeneticVariantsintheMAP4K4
LocuswithPrediabeticTraitsinHumans
TinaSartorius1,2,3.,HaraldStaiger1,2,3.,CarolineKetterer2,3,MartinHeni3,FaustoMachicao1,2,
AdilsonGuilherme4,HaraldGrallert2,5,MatthiasB.Schulze2,6,HeinerBoeing2,7,NorbertStefan1,2,3
,
AndreasFritsche1,2,3,8,MichaelP.Czech4,Hans-UlrichHa¨ring1,2,3*
1Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tu¨bingen, Tu¨bingen, Germany, 2German Center for
Diabetes Research (DZD), Neuherberg, Germany, 3Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal
Medicine, Eberhard Karls University Tu¨bingen, Tu¨bingen, Germany, 4Program in Molecular Medicine, University of Massachusetts Medical School, Worcester,
Massachusetts, United States of America, 5Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Centre Munich, German Research Center for
EnvironmentalHealth,Neuherberg,Germany,6DepartmentofMolecularEpidemiology,GermanInstituteofHumanNutritionPotsdam-Rehbruecke,Nuthetal,Germany,
7Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany, 8Division of Nutritional and Preventive Medicine,
DepartmentofInternalMedicine,EberhardKarlsUniversityTu¨bingen,Tu¨bingen,Germany
Abstract
Mitogen-activatedproteinkinasekinasekinasekinase4(MAP4K4)isexpressedinalldiabetes-relevanttissuesandmediates
cytokine-induced insulin resistance. We investigated whether common single nucleotide polymorphisms (SNPs) in the
MAP4K4locusassociatewithglucoseintolerance,insulinresistance,impairedinsulinrelease,orelevatedplasmacytokines.
Thebesthitwastestedforassociationwithtype2diabetes.Subjects(N=1,769)wererecruitedfromtheTu¨bingenFamily
¨
(TUF)studyfortype2diabetesandgenotypedfortaggingSNPs.Inasubgroup,cytokinesweremeasured.Associationwith
type2diabeteswastestedinaprospectivecase-cohortstudy(N=2,971)derivedfromtheEPIC-Potsdamstudy.ThreeSNPs
(rs654308
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