Association of Gender with Clinical Expression, Quality of Life, Disability, and Depression and Anxiety in Patients with Systemic Sclerosis 英文参考文献.docVIP
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Association of Gender with Clinical Expression, Quality of Life, Disability, and Depression and Anxiety in Patients with Systemic Sclerosis 英文参考文献
AssociationofGenderwithClinicalExpression,Qualityof
Life,Disability,andDepressionandAnxietyinPatients
withSystemicSclerosis
ChristelleNguyen1,2,AliceBe′rezne′1,ThierryBaubet3,CarolineMestre-Stanislas1,Franc?oisRannou2,
AgathePapelard2,SandrineMorell-Dubois4,MichelRevel2,Lo?¨cGuillevin1,SergePoiraudeau2,
LucMouthon1*,onbehalfoftheGroupeFranc?ais deRecherchesurlaScle′rodermie
1Universite′ ParisDescartes,Faculte′ deMe′decineParisDescartes,Po?ledeMe′decineInterne,CentredeRe′fe′rencepourlesVascularitesNe′crosantesetlaScle′rodermie
Syste′mique, Ho?pital Cochin, Assistance Publique-Ho?pitaux de Paris (AP-HP), Paris, France, 2Universite′ Paris Descartes, Faculte′ de Me′decine Paris Descartes, Institut
Fe′de′ratifdeRecherchesurleHandicap,ServicedeMe′decinePhysiqueetdeRe′adaptation,Ho?pitalCochin,AP-HP,Paris,France,3Universite′ParisXIII,EA3413,Servicede
Psychopathologie,Ho?pitalAvicenne,AP-HP,Bobigny, France,4Universite′ Lille2,ServicedeMe′decine Interne, CentredeRe′fe′rence pourlaScle′rodermieSyste′mique,
Ho?pitalClaudeHuriez,Lille,France
Abstract
Objectives:Toassesstheassociationofgenderwithclinicalexpression,health-relatedqualityoflife(HRQoL),disability,and
self-reportedsymptomsofdepressionandanxietyinpatientswithsystemicsclerosis(SSc).
Methods: SSc patients fulfilling the American College of Rheumatology and/or the Leroy and Medsger criteria were
assessed for clinical symptoms, disability, HRQoL, self-reported symptoms of depression and anxiety by specific
measurementscales.
Results:Overall,381SScpatients(62males)wereincluded.Meanageanddiseasedurationatthetimeofevaluationwere
55.9(13.3)and9.5(7.8)years,respectively.One-hundred-and-forty-nine(40.4%)patientshaddiffusecutaneousSSc(dcSSc).
On bivariate analysis, differences were observed between males and females for clinical symptoms and self-reported
symptoms of depression and anxiety, however without reaching statistical significance. Indeed, a trend was found for
higherbodymassindex(BMI)(25.0[4.1]vs23.0[4.5],
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