Association of Group B Streptococcus Colonization and Bovine Exposure A Prospective Cross-Sectional Cohort Study 英文参考文献.docVIP

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Association of Group B Streptococcus Colonization and Bovine Exposure A Prospective Cross-Sectional Cohort Study 英文参考文献.doc

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Association of Group B Streptococcus Colonization and Bovine Exposure A Prospective Cross-Sectional Cohort Study 英文参考文献

AssociationofGroupBStreptococcusColonizationand BovineExposure:AProspectiveCross-SectionalCohort Study ShannonD.Manning1,2,3,A.CodySpringman1,2,3,AmberD.Million1,2,NicoleR.Milton1,2,3,SaraE. McNamara4,PatriciaA.Somsel4,PaulBartlett2,H.DeleDavies3* 1MicrobialEvolutionLaboratory,MichiganStateUniversity,EastLansing,Michigan,UnitedStatesofAmerica,2NationalFoodSafetyandToxicologyCenter,Michigan State University, East Lansing, Michigan, United States of America, 3Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan,UnitedStatesofAmerica,4BureauofLaboratories,MichiganDepartmentofCommunityHealth,Lansing,Michigan,UnitedStatesofAmerica Abstract Background:WhileGroupBStreptococcus(GBS)humancolonizationandinfectionhaslongbeensuspectedasoriginating fromcows,severalinvestigatorshavesuggestedthatongoinginterspeciesGBStransmissionisunlikelyduetogenotyping datademonstrating that humanandbovine-derived GBSstrains representmostly distinct populations. Thepossibility of ongoingtransmissionbetweenhumansandtheirlivestockhasnotbeensystematicallyexamined. Methodology/Principal Findings: To examine ongoing interspecies transmission, we conducted a prospective cross- sectionalcohortstudyof68familiesandtheirlivestock.Stoolspecimenswerecollectedfrom154peopleand115livestock; GBS was detected in 19 (12.3%) humans and 2 (1.7%) animals (bovine and sheep). Application of multilocus sequence typing(MLST)identified8sequencetypes(STsorclones),withSTs1and23predominating.Therewere11familiesinwhich twomemberssubmittedstoolsandatleastonehadGBScolonization.In3ofthesefamilies,bothmembers(consistingof couples)werecolonized,yieldingaco-colonizationrateof27%(95%CI:7%–61%).Twoofthesecoupleshadstrainswith identicalMLST,capsule(cps)genotype,susceptibility,andRAPDprofiles.Onecoupleco-colonizedwithST-1(cps5)strains alsohadabovinecolonizedwiththeidenticalstraintype.Onmultivariateanalysisofquestionnairedata,cattleexposure wasapredictorofGBScolonization,witheachunitincre