Association of Human Herpesvirus-6B with Mesial Temporal Lobe Epilepsy 英文参考文献.docVIP

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Association of Human Herpesvirus-6B with Mesial Temporal Lobe Epilepsy 英文参考文献.doc

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Association of Human Herpesvirus-6B with Mesial Temporal Lobe Epilepsy 英文参考文献

o PL SMEDICINE AssociationofHumanHerpesvirus-6Bwith MesialTemporalLobeEpilepsy Julie Fotheringham1,Donatella Donati1,2,Nahid Akhyani1,Anna Fogdell-Hahn1,3,Alexander Vortmeyer4, John D.Heiss4,Elizabeth Williams1,Steven Weinstein5,Derek A.Bruce5,William D.Gaillard5,6,Susumu Sato6, William H.Theodore6,Steven Jacobson1* 1ViralImmunologySection,NationalInstituteofNeurologicalDisordersandStroke,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica,2Struttura Complessa di Microbiologia e Virologia, Azienda Ospedaliera Universitaria Senese, Siena, Italy, 3 Department of Clinical Neuroscience, Division of Neurology, Karolinska Institutet,Stockholm,Sweden,4SurgicalNeurologyBranch,NationalInstituteofNeurologicalDisordersandStroke,NationalInstitutesofHealth,Bethesda,Maryland,United States of America, 5 Children’s National Medical Center, Washington, District of Columbia, United States of America, 6 Clinical Epilepsy Section, National Institute of NeurologicalDisordersandStroke,NationalInstitutesofHealth,Maryland,UnitedStatesofAmerica Funding:Fundingforthisstudywas providedbytheNationalInstitutes ofHealth.Thefundershadnorolein studydesign,datacollectionand analysis,decisiontopublish,or preparationofthemanuscript. ABSTRACT Background Human herpesvirus-6 (HHV-6) is a b-herpesvirus with 90% seroprevalence that infects and establisheslatencyinthecentralnervoussystem.TwoHHV-6variantsareknown:HHV-6Aand HHV-6B.ActiveinfectionorreactivationofHHV-6inthebrainisassociatedwithneurological disorders, including epilepsy, encephalitis, and multiple sclerosis. In a preliminary study, we foundHHV-6BDNAinresectedbraintissuefrompatientswithmesialtemporallobeepilepsy (MTLE)andhavelocalizedviralantigentoglialfibrillaryacidicprotein(GFAP)–positivegliain thesamebrainsections.Wesought,first,todeterminetheextentofHHV-6infectioninbrain materialresectedfromMTLEandnon-MTLEpatients;andsecond,toestablishinvitroprimary astrocyteculturesfromfreshlyresectedbrainmaterialanddetermineexpressio