Association of HbA1c Values with Mortality and Cardiovascular Events in Diabetic Dialysis Patients. The INVOR Study and Review of the Literature 英文参考文献.docVIP
- 1、本文档共8页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Association of HbA1c Values with Mortality and Cardiovascular Events in Diabetic Dialysis Patients. The INVOR Study and Review of the Literature 英文参考文献
AssociationofHbA1cValueswithMortalityand
CardiovascularEventsinDiabeticDialysisPatients.The
INVORStudyandReviewoftheLiterature
GiselaSturm1,ClaudiaLamina1,EmanuelZitt2,3,KarlLhotta2,3,FlorianHaider1,UlrichNeyer2,3 ,Florian
Kronenberg1*
1DivisionofGeneticEpidemiology,DepartmentofMedicalGenetics,MolecularandClinicalPharmacology,InnsbruckMedicalUniversity,Innsbruck,Austria,2Department
ofNephrologyandDialysis,AcademicTeachingHospitalFeldkirch,Feldkirch,Austria, 3VorarlbergInstituteforVascularInvestigationandTreatment(VIVIT),Feldkirch,
Austria
Abstract
Background: Improved glycemic control reduces complications in patients with diabetes mellitus (DM). However, it is
discussedcontroversiallywhetherpatientswithdiabetesmellitusandend-stagerenaldiseasebenefitfromstrictglycemic
control.
Methods:Wefollowed78patientswithDMinitiatingdialysistreatmentoftheregionofVorarlberginaprospectivecohort
studyapplyingatime-dependentCoxregressionanalysisusingallmeasuredlaboratoryvaluesforuptomorethanseven
years.Thisresultedin880HbA1cmeasurements(withonemeasurementevery3.16patientmonthsonaverage)duringthe
entireobservationperiod.Non-linearP-splineswereusedtoallowflexiblemodelingoftheassociationwithmortalityand
cardiovasculardisease(CVD)events.
Results: We observed a decreased mortality risk with increasing HbA1c values (HR=0.72 per 1% increase, p=0.024).
AdjustmentforageandsexandadditionaladjustmentforotherCVDriskfactorsonlyslightlyattenuatedtheassociation
(HR=0.71,p=0.044).Anon-linearP-splineshowedthattheassociationdidnotfollowafullylinearpatternwithahighly
significant non-linear component (p=0.001) with an increased risk of all-cause mortality for HbA1c values up to 6–7%.
Causes of death were associated with HbA1c values. The risk for CVD events, however, increased with increasing HbA1c
values(HR=1.24per1%increase,p=0.048)butvanishedafterextendedadjustments.
Conclusions: This study considered the entire information collected on HbA1c over a period of more than seven years.
Besidesthe
您可能关注的文档
- Assessment of the Quality of Reporting in Abstracts of Randomized Controlled Trials Published in Five Leading Chinese Medical Journals 英文参考文献.doc
- Assessment of the Antiviral Properties of Recombinant Porcine SP-D against Various Influenza A Viruses In Vitro 英文参考文献.doc
- Assessment of Yellow Fever Epidemic Risk An Original Multi-criteria Modeling Approach 英文参考文献.doc
- Assessment of the N-PCR Assay in Diagnosis of Pleural Tuberculosis Detection of M.tuberculosis in Pleural Fluid and Sputum Collected in Tandem 英文参考文献.doc
- Assimilating Seizure Dynamics 英文参考文献.doc
- ASSET (AgeSex Standardised Estimates of Treatment) A Research Model to Improve the Governance of Prescribing Funds in Italy 英文参考文献.doc
- ASSIST Applicability Scoring of Surgical trials. An Investigator-reported aSsessment Tool 英文参考文献.doc
- Assignment of PolyProline II Conformation and Analysis of Sequence – Structure Relationship 英文参考文献.doc
- Assessment of Volume Depletion in Children with Malaria 英文参考文献.doc
- Associating Genes and Protein Complexes with Disease via Network Propagation 英文参考文献.doc
文档评论(0)