Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination 英文参考文献.docVIP
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Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination 英文参考文献
AssociationofInteractingGenesintheToll-Like
ReceptorSignalingPathwayandtheAntibodyResponse
toPertussisVaccination
TjeerdG.Kimman1,2*,SanderBanus1,NaomiReijmerink3,JohanReimerink1,FoekjeF.Stelma4,GerardH.
Koppelman5,CarelThijs6,DirkjeS.Postma3,MarjanKerkhof7
1CenterforInfectiousDiseaseControl,NationalInstituteofPublicHealthandtheEnvironment,Bilthoven,TheNetherlands,2CentralVeterinaryInstitute,Lelystad,The
Netherlands, 3Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 4Department of Medical
Microbiology,AcademicHospitalMaastricht,Maastricht,TheNetherlands,5DepartmentofPediatricPulmonologyandPediatricAllergology,BeatrixChildren’sHospital,
UniversityMedicalCenterGroningen,UniversityofGroningen,Groningen,TheNetherlands,6DepartmentofEpidemiology,SchoolofPublicHealthandPrimaryCare
(Caphri), and Nutrition and Toxicology Research Institute Maastricht (Nutrim), Maastricht University, Maastricht, The Netherlands, 7Department of Epidemiology,
UniversityMedicalCenterGroningen,UniversityofGroningen,Groningen,TheNetherlands
Abstract
Background:ActivationoftheToll-likereceptor(TLR)signalingpathwaythroughTLR4maybeimportantintheinductionof
protectiveimmunityagainstBordetellapertussiswithTLR4-mediatedactivationofdendriticandBcells,inductionofcytokine
expression, and reversal of tolerance as crucial steps. We examined whether single nucleotide polymorphisms (SNPs) in
genesoftheTLR4 pathwayandtheirinteraction areassociatedwith theresponsetowhole-cellvaccine (WCV)pertussis
vaccinationin490one-year-oldchildren.
Methodology/PrincipalFindings:Weanalyzedassociationsof75haplotype-taggingSNPsingenesintheTLR4signaling
pathwaywithpertussistoxin(PT)-IgGtiters.WefoundsignificantassociationsbetweenthePT-IgGtiterandSNPsinCD14,
TLR4, TOLLIP, TIRAP, IRAK3, IRAK4, TICAM1, and TNFRSF4 in one or more of the analyses. The strongest evidence for
association was found for two SNPs (rs5744034 and rs5743894) in TOLLIP that were almost
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