Autoantibodies against the Catalytic Domain of BRAF Are Not Specific Serum Markers for Rheumatoid Arthritis 英文参考文献.docVIP
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Autoantibodies against the Catalytic Domain of BRAF Are Not Specific Serum Markers for Rheumatoid Arthritis 英文参考文献
AutoantibodiesagainsttheCatalyticDomainofBRAF
AreNotSpecificSerumMarkersforRheumatoidArthritis
WenliLi1,2,WeiWang1,2,ShipengSun1,2,YuSun1,2,YangPan1,2,LunanWang1,RuiZhang1,KuoZhang1,
JinmingLi1*
1NationalCenterforClinicalLaboratories,BeijingHospital,Beijing,People’sRepublicofChina,2GraduateSchool,PekingUnionMedicalCollege,ChineseAcademyof
MedicalSciences,Beijing,People’sRepublicofChina
Abstract
Background:Autoantibodiestothecatalyticdomainofv-rafmurinesarcomaviraloncogenehomologueB1(BRAF)have
beenrecentlyidentifiedasanewfamilyofautoantibodiesinvolvedinrheumatoidarthritis(RA).Theobjectiveofthisstudy
was to determine antibody responses to the catalytic domain of BRAF in RA and other autoimmune diseases. The
associationbetweenRA-relatedclinicalindicesandtheseantibodieswasalsoassessed.
Methodology/PrincipalFindings:ThepresenceofautoantibodiestothecatalyticdomainofBRAF(anti-BRAF)ortopeptide
P25(aminoacids656–675ofthecatalyticdomainofBRAF;anti-P25)wasdeterminedinserumsamplesfrompatientswith
RA,primarySjo¨gren’ssyndrome(pSS),systemiclupuserythematosus(SLE),andhealthycontrolsbyusingindirectenzyme-
linked immunosorbent assays (ELISAs) based on the recombinant catalytic domain of BRAF or a synthesized peptide,
respectively. Associations of anti-BRAF or anti-P25 with disease variables of RA patients were also evaluated. Our results
showthattheBRAF-specificantibodiesanti-BRAFandanti-P25areequallypresentinRA,pSS,andSLEpatients.However,
theerythrocytesedimentationrate(ESR)usedtodetectinflammationwassignificantlydifferentbetweenpatientswithand
withoutBRAF-specificantibodies.Theanti-BRAF-positivepatientswerefoundtohaveprolongeddisease,andactivedisease
occurredmorefrequentlyinanti-P25-positivepatientsthaninanti-P25-negativepatients.Aweakbutsignificantcorrelation
betweenanti-P25levelsandESRswasobserved(r=0.319,p=0.004).
Conclusions/Significance:TheantibodyresponseagainstthecatalyticdomainofBRAFisnotspecificforRA,butthehigher
titersofBRAF-specificantibodiesmaybeassociatedwithincreas
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