AutoEPG Software for the Analysis of Electrical Activity in the Microcircuit Underpinning Feeding Behaviour of Caenorhabditis elegans 英文参考文献.docVIP

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AutoEPG Software for the Analysis of Electrical Activity in the Microcircuit Underpinning Feeding Behaviour of Caenorhabditis elegans 英文参考文献.doc

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AutoEPG Software for the Analysis of Electrical Activity in the Microcircuit Underpinning Feeding Behaviour of Caenorhabditis elegans 英文参考文献

AutoEPG:SoftwarefortheAnalysisofElectricalActivity intheMicrocircuitUnderpinningFeedingBehaviourof Caenorhabditiselegans JamesDillon1.*,IoannisAndrianakis2.,KateBull1,SteveGlautier3,VincentO’Connor1 ,Lindy Holden-Dye1,ChristopherJames2 1SchoolofBiologicalSciences,BassettCrescentEast,UniversityofSouthampton,Southampton,UnitedKingdom, 2Signal ProcessingandControl Group,Institute of SoundandVibrationResearch,UniversityofSouthampton,Southampton,UnitedKingdom,3SchoolofPsychology,UniversityofSouthampton,Southampton,United Kingdom Abstract Background:ThepharyngealmicrocircuitofthenematodeCaenorhabditiselegansservesasamodelforanalysingneural network activity and is amenable to electrophysiological recording techniques. One such technique is the electropharyngeogram (EPG) which has provided insight into the genetic basis of feeding behaviour, neurotransmission and muscle excitability. However, the detailed manual analysis of the digital recordings necessary to identify subtle differences in activity that reflect modulatory changes within the underlying network is time consuming and low throughput.Toaddressthiswehavedevelopedanautomatedsystemforthehigh-throughputanddiscreteanalysisofEPG recordings(AutoEPG). Methodology/PrincipalFindings:AutoEPGemploysatailormadesignalprocessingalgorithmthatautomaticallydetects differentfeaturesoftheEPGsignalincludingthosethatreportontherelaxationandcontractionofthemuscleandneuronal activity.ManualverificationofthedetectionalgorithmhasdemonstratedAutoEPGiscapableofveryhighlevelsofaccuracy. Wehavefurthervalidatedthesoftwarebyanalysingexistingmutantstrainswithknownpharyngealphenotypesdetectable by the EPG. In doing so, we have more precisely defined an evolutionarily conserved role for the calcium-dependent potassiumchannel,SLO-1,inmodulatingtherhythmicactivityofneuralnetworks. Conclusions/Significance: AutoEPG enables the consistent analysis of EPG recordings, significantly increases analysis throughput and allows the robust iden