Atoh8, a bHLH Transcription Factor, Is Required for the Development of Retina and Skeletal Muscle in Zebrafish 英文参考文献.docVIP

下载本文档

8
0
约3.63万字
约 13页
2017-05-11 发布于上海
举报
版权申诉

Atoh8, a bHLH Transcription Factor, Is Required for the Development of Retina and Skeletal Muscle in Zebrafish 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Atoh8, a bHLH Transcription Factor, Is Required for the Development of Retina and Skeletal Muscle in Zebrafish 英文参考文献

Atoh8,abHLHTranscriptionFactor,IsRequiredforthe DevelopmentofRetinaandSkeletalMuscleinZebrafish JihuaYao1*,JingyaoZhou1,QiaolingLiu2,DaruLu1,LuWang1,XiaojingQiao1,WilliamJia1,3* 1State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China, 2Pathology Laboratory, Shanghai ResearchCenterforBiomodelOrganisms,Shanghai,China,3DepartmentofSurgery,UniversityofBritishColumbia,Vancouver,Canada Abstract Background: Math6/atoh8,abHLHtranscriptionfactor,isthoughttobeindispensableforearlyembryonicdevelopment and likely has important roles in vertebrate tissue-specific differentiation. However, the function of Atoh8 during early developmentisnotclearbecausehomozygousknockoutcausesembryoniclethalityinmice.Wehaveexaminedtheeffects oftheatoh8geneonthedifferentiationofretinaandskeletalmuscleduringearlydevelopmentinzebrafish. Results:WeisolatedaMath6homologueinzebrafish,designatedaszebrafish atoh8.Whole-mountinsituhybridization analysisshowedthatzebrafishatoh8isdynamicallyexpressedmainlyindevelopingretinaandskeletalmuscle.Atoh8-MO knock-downresultedinreducedeyesizewithdisorganizationofretinallamination.Thereductionofatoh8functionalso affectedthearrangementofparaxialcellsanddifferentiatedmusclefibersduringsomitemorphogenesis. Conclusion: Our results show that Atoh8 is an important regulator for the development of both the retina and skeletal musclesnecessaryforneuralretinalcellandmyogenicdifferentiationduringzebrafishembryogenesis. Citation:YaoJ,ZhouJ,LiuQ,LuD,WangL,etal.(2010)Atoh8,abHLHTranscriptionFactor,IsRequiredfortheDevelopmentofRetinaandSkeletalMusclein Zebrafish.PLoSONE5(6):e10945.doi:10.1371/journal.pone.0010945 Editor:BruceRiley,TexasAMUniversity,UnitedStatesofAmerica ReceivedNovember1,2009;AcceptedMay12,2010;PublishedJune3,2010 Copyright:?2010Yaoetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanyme