Association of Mycobacterium avium subsp. paratuberculosis with Multiple Sclerosis in Sardinian Patients 英文参考文献.docVIP

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Association of Mycobacterium avium subsp. paratuberculosis with Multiple Sclerosis in Sardinian Patients 英文参考文献.doc

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Association of Mycobacterium avium subsp. paratuberculosis with Multiple Sclerosis in Sardinian Patients 英文参考文献

AssociationofMycobacteriumaviumsubsp. paratuberculosiswithMultipleSclerosisinSardinian Patients DavideCossu1,EleonoraCocco2,DanielaPaccagnini1,SperanzaMasala1,NiyazAhmed3,4,JessicaFrau2, MariaGiovannaMarrosu2,LeonardoA.Sechi1* 1Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Universita` di Sassari, Sassari, Italy, 2Centro Sclerosi Multipla, Dipartimento di Scienze CardiovascolarieNeurologiche,Universita` diCagliari,Cagliari,Italy,3PathogenBiologyLaboratory,DepartmentofBiotechnology,SchoolofLifeSciences,Universityof Hyderabad,Hyderabad,India,4InstituteofBiologicalSciences,UniversityofMalaya,KualaLumpur,Malaysia Abstract Mycobacterium avium subsp. paratuberculosis (MAP) infection is highly spread in the ruminant herds of Sardinia, in the Western Mediterranean. The objective of this study was to investigate prevalence of MAP infection in association with MultipleSclerosis(MS)usingclinicalspecimenfrompatientsandcontrols.WeanalyzedsamplesforthepresenceofMAP specific DNA and to demonstrate humoral response to a MAP protein (MAP2694), a predicted homologue of the T-cell receptorgamma-chain/complementcomponent1ofthehost.WefoundpresenceofMAPDNAin42%oftheMSpatients and an extremely significant humoral immune response revealed by the MS patients against the MAP protein. In our opinion,thisisthefirstreportthatsignificantlyassociatesMAPinfectionwithMS.Furtherstudieswillberequiredtoconfirm ifMAPcouldbeoneofthetriggersofMS,accordingtothemolecularmimicrytheory,insusceptible(andgeneticallyatrisk) individuals. Citation:CossuD,CoccoE,PaccagniniD,MasalaS,AhmedN,etal.(2011)AssociationofMycobacteriumaviumsubsp.paratuberculosiswithMultipleSclerosisin SardinianPatients.PLoSONE6(4):e18482.doi:10.1371/journal.pone.0018482 Editor:DeliaGoletti,NationalInstituteforInfectiousDiseases(L.Spallanzani),Italy ReceivedJanuary26,2011;AcceptedMarch1,2011;PublishedApril13,2011 Copyright: ? 2011 Cossu et al. This is an open-access article distributed under the terms of the Cre