Association of Human Papillomavirus Infection and Abnormal Anal Cytology among HIV-Infected MSM in Beijing, China 英文参考文献.docVIP
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Association of Human Papillomavirus Infection and Abnormal Anal Cytology among HIV-Infected MSM in Beijing, China 英文参考文献
AssociationofHumanPapillomavirusInfectionand
AbnormalAnalCytologyamongHIV-InfectedMSMin
Beijing,China
YuYang1.,XiangweiLi1.,ZhihuiZhang2,Han-ZhuQian3,YuhuaRuan4,FengZhou1,CongGao1,
MufeiLi1,QiJin1*,LeiGao1*
1MOHKeyLaboratoryofSystemsBiologyofPathogens,InstituteofPathogenBiology,ChineseAcademyofMedicalSciencesPekingUnionMedicalCollege,Beijing,
China,2HospitalofCancer,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing,China,3VanderbiltInstituteforGlobalHealth,andDivision
ofEpidemiology,VanderbiltUniversitySchoolofMedicine,Nashville,Tennessee,UnitedStatesofAmerica,4StateKeyLaboratoryforInfectiousDiseasePreventionand
Control,NationalCenterforAIDS/STDControlandPrevention,ChineseCenterforDiseaseControlandPrevention,Beijing,China
Abstract
Background:Intherecentyears,dramaticincreasesinHIVtransmissionamongmenwhohavesexwithmen(MSM)have
beenobservedinChina.Humanpapillomavirus(HPV)infectionrelatedanalcancerismorecommonamongHIV-infected
MSMascomparedtothegeneralpopulation.However, HPVinfectionandanalcytologyhasbeenrarelystudiedin HIV-
infectedMSMinChina.
Methods:HIV-infectedMSMinBeijing,ChinawereinvitedtoparticipateinthisstudybetweenJanuaryandApril2011.Anal
swabswerecollectedforexaminingcytologyandHPVgenotypes.
Results: Ninety-fiveeligibleparticipants withcompletequestionnaire andlaboratorydatawereincluded intheanalyses.
Thirtysixofthem(37.9%)showedabnormalanalcytologyasfollows:atypicalsquamouscellsofundeterminedsignificance
(ASC-US) in 19 (20.0%), atypical squamous cells but cannot exclude HSIL (ASC-H) in 1 (1.1%), low-grade squamous
intraepitheliallesion(LSIL)in15(15.8%),andhigh-gradesquamousintraepitheliallesion(HSIL)in1(1.1%).HPV6(20.0%),
HPV16(10.9%),HPV56(10.9%),HPV52(9.1%)andHPV39(9.1%)wereobservedmostfrequentlyamongthosewithnormal
anal cytology, while different distribution was found in the ones with abnormal anal cytology as HPV6 (19.4%), HPV16
(19.4%),HPV45(16.7%),HPV52(16.7%)andHPV18(11.1%).Inaddition,HPV16,HPV45,HPV52andHPV18werethemos
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