Association of Human Papillomavirus Infection and Abnormal Anal Cytology among HIV-Infected MSM in Beijing, China 英文参考文献.docVIP

Association of Human Papillomavirus Infection and Abnormal Anal Cytology among HIV-Infected MSM in Beijing, China 英文参考文献.doc

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Association of Human Papillomavirus Infection and Abnormal Anal Cytology among HIV-Infected MSM in Beijing, China 英文参考文献

AssociationofHumanPapillomavirusInfectionand AbnormalAnalCytologyamongHIV-InfectedMSMin Beijing,China YuYang1.,XiangweiLi1.,ZhihuiZhang2,Han-ZhuQian3,YuhuaRuan4,FengZhou1,CongGao1, MufeiLi1,QiJin1*,LeiGao1* 1MOHKeyLaboratoryofSystemsBiologyofPathogens,InstituteofPathogenBiology,ChineseAcademyofMedicalSciencesPekingUnionMedicalCollege,Beijing, China,2HospitalofCancer,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing,China,3VanderbiltInstituteforGlobalHealth,andDivision ofEpidemiology,VanderbiltUniversitySchoolofMedicine,Nashville,Tennessee,UnitedStatesofAmerica,4StateKeyLaboratoryforInfectiousDiseasePreventionand Control,NationalCenterforAIDS/STDControlandPrevention,ChineseCenterforDiseaseControlandPrevention,Beijing,China Abstract Background:Intherecentyears,dramaticincreasesinHIVtransmissionamongmenwhohavesexwithmen(MSM)have beenobservedinChina.Humanpapillomavirus(HPV)infectionrelatedanalcancerismorecommonamongHIV-infected MSMascomparedtothegeneralpopulation.However, HPVinfectionandanalcytologyhasbeenrarelystudiedin HIV- infectedMSMinChina. Methods:HIV-infectedMSMinBeijing,ChinawereinvitedtoparticipateinthisstudybetweenJanuaryandApril2011.Anal swabswerecollectedforexaminingcytologyandHPVgenotypes. Results: Ninety-fiveeligibleparticipants withcompletequestionnaire andlaboratorydatawereincluded intheanalyses. Thirtysixofthem(37.9%)showedabnormalanalcytologyasfollows:atypicalsquamouscellsofundeterminedsignificance (ASC-US) in 19 (20.0%), atypical squamous cells but cannot exclude HSIL (ASC-H) in 1 (1.1%), low-grade squamous intraepitheliallesion(LSIL)in15(15.8%),andhigh-gradesquamousintraepitheliallesion(HSIL)in1(1.1%).HPV6(20.0%), HPV16(10.9%),HPV56(10.9%),HPV52(9.1%)andHPV39(9.1%)wereobservedmostfrequentlyamongthosewithnormal anal cytology, while different distribution was found in the ones with abnormal anal cytology as HPV6 (19.4%), HPV16 (19.4%),HPV45(16.7%),HPV52(16.7%)andHPV18(11.1%).Inaddition,HPV16,HPV45,HPV52andHPV18werethemos

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