Automated DNA Sequence-Based Early Warning System for the Detection of Methicillin-Resistant Staphylococcus aureus Outbreaks 英文参考文献.docVIP

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Automated DNA Sequence-Based Early Warning System for the Detection of Methicillin-Resistant Staphylococcus aureus Outbreaks 英文参考文献.doc

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Automated DNA Sequence-Based Early Warning System for the Detection of Methicillin-Resistant Staphylococcus aureus Outbreaks 英文参考文献

o PL SMEDICINE AutomatedDNASequence-BasedEarlyWarning SystemfortheDetectionofMethicillin- ResistantStaphylococcusaureusOutbreaks Alexander Mellmann1,Alexander W. Friedrich1,Nicole Rosenko¨tter2,Jo¨rgRothga¨nger3,Helge Karch1,Ralf Reintjes2, Dag Harmsen4* 1InstituteforHygiene,UniversityHospitalMu¨nster,Mu¨nster,Germany,2HamburgUniversityofAppliedSciences,Hamburg,Germany,3RidomGmbH,Wu¨rzburg,Germany, 4DepartmentofPeriodontology,UniversityHospitalMu¨nster,Mu¨nster,Germany CompetingInterests:JR,HK,and DHhavedeclaredapotentialconflict ofinterest.JRandDHarethe developersoftheRidomStaphType softwarementionedinthe ABSTRACT Background The detection of methicillin-resistant Staphylococcus aureus (MRSA) usually requires the implementationofoftenrigorousinfection-controlmeasures.PromptidentificationofanMRSA epidemic is crucial for the control of an outbreak. In this study we evaluated various early warningalgorithmsforthedetectionofanMRSAcluster. manuscript.Thesoftwareis distributedandsoldbythecompany RidomGmbHthatispartiallyowned bythem.HKisascientificadvisorof thiscompany.Allotherauthorshave declaredthatnocompeting interestsexist. MethodsandFindings AuthorContributions:AM,AWF,HK, andDHdesignedthestudy.AM,AWF, NR,JR,RR,andDHanalyzedthedata. AM,AWF,NR,HK,RR,andDH contributedtowritingthepaper.HK supervisedtheclinicalsampleand datacollection.AWFheadedtheICP team.AMdidthelaboratory identificationandstrainanalysis.JR andDHdevelopedtheRidom StaphTypesoftware.AMandDHwrote themainpartofthepaper.Allauthors gaveusefulcommentontheanalysis ofdataandtextofthemanuscript. Between 1998 and 2003, 557 non-replicate MRSA strains were collected from staff and patients admitted to a German tertiary-care university hospital. The repeat region of the S. aureusproteinA(spa)geneineachofthesestrainswassequenced.Usingepidemiologicaland typing information for the period 1998–2002 as reference data, clusters in 2003 were determined by temporal-scan test statistics. Various early warning algorithms (