Blood Levels of Macrophage Migration Inhibitory Factor after Successful Resuscitation from Cardiac Arrest 英文参考文献.docVIP

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Blood Levels of Macrophage Migration Inhibitory Factor after Successful Resuscitation from Cardiac Arrest 英文参考文献.doc

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Blood Levels of Macrophage Migration Inhibitory Factor after Successful Resuscitation from Cardiac Arrest 英文参考文献

BloodLevelsofMacrophageMigrationInhibitoryFactor afterSuccessfulResuscitationfromCardiacArrest ChristianStoppe1,2*.,MichaelFries3.,RolfRossaint1,GerritGrieb2,4,MarkCoburn1,DavidSimons2,4, DavidBru¨cken5,Ju¨rgenBernhagen2,NorbertPallua4,SteffenRex1 1DepartmentofAnaesthesiology,UniversityHospitaloftheRWTHAachen,Aachen,Germany,2InstituteofBiochemistryandMolecularCellBiology,UniversityHospital oftheRWTHAachen,Aachen,Germany,3DepartmentofIntensiveCare,UniversityHospitaloftheRWTHAachen,Aachen,Germany,4DepartmentofPlasticSurgery, HandSurgery,BurnUnit,UniversityHospitaloftheRWTHAachen,Aachen,Germany,5DepartmentofOrthopaedicsandTraumaSurgery(mainfocusontraumasurgery), UniversityHospitaloftheRWTHAachen,Aachen,Germany Abstract Introduction: Ischemia-reperfusion injury following cardiopulmonary resuscitation (CPR) is associated with a systemic inflammatory response, resulting in post-resuscitation disease. In the present study we investigated the response of the pleiotropicinflammatorycytokinemacrophagemigrationinhibitoryfactor(MIF)toCPRinpatientsadmittedtothehospital afterout-of-hospitalcardiacarrest(OHCA).TodescribethemagnitudeofMIFrelease,wecomparedthebloodlevelsfrom CPR patients with those obtained in healthy volunteers and with an aged- and gender-matched group of patients undergoingcardiacsurgerywiththeuseofextracorporealcirculation. Methods: Blood samples of 17 patients with return of spontaneous circulation (ROSC) after OHCA were obtained upon admissiontotheintensivecareunit,and6,12,24,72and96hlater.Arrestandtreatmentrelateddataweredocumented accordingtotheUtsteinstyle. Results: In patients after ROSC, MIF levels at admission (475.26157.8ng/ml) were significantly higher than in healthy volunteers (12.5616.9ng/ml, p,0.007) and in patients after cardiac surgery (78.2641.6ng/ml, p,0.007). Six hours after admission,MIFlevelsweredecreasedbymorethan50%(150.56127.2ng/ml,p,0.007),butwerenotfurtherreducedin the subsequent time course and remained significantly higher than the