Blood Glucose and Risk of Incident and Fatal Cancer in the Metabolic Syndrome and Cancer Project (Me-Can) Analysis of Six Prospective Cohorts 英文参考文献.docVIP

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Blood Glucose and Risk of Incident and Fatal Cancer in the Metabolic Syndrome and Cancer Project (Me-Can) Analysis of Six Prospective Cohorts 英文参考文献.doc

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Blood Glucose and Risk of Incident and Fatal Cancer in the Metabolic Syndrome and Cancer Project (Me-Can) Analysis of Six Prospective Cohorts 英文参考文献

BloodGlucoseandRiskofIncidentandFatalCancerin theMetabolicSyndromeandCancerProject(Me-Can): AnalysisofSixProspectiveCohorts TanjaStocks1*,KilianRapp2,ToneBj?rge3,4,JonasManjer5,HannoUlmer6,RandiSelmer7 ,Annekatrin Lukanova8,DortheJohansen5,HansConcin9,SteinarTretli10,Go¨ranHallmans11,Ha?kanJonsson12,Pa¨r Stattin1 1DepartmentofSurgicalandPerioperativesciences,UrologyandAndrology,Umea?University,Umea?,Sweden,2InstituteofEpidemiology,UlmUniversity,Ulm,Germany, 3DepartmentofPublicHealthandPrimaryHealthCare,UniversityofBergen,Bergen,Norway,4NorwegianInstituteofPublicHealth,Bergen,Norway,5Departmentof Surgery, Malmo¨ University Hospital, Malmo¨, Sweden, 6Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria,7DivisionofEpidemiology,NorwegianInstituteofPublicHealth,Oslo,Norway,8DivisionofCancerEpidemiology,GermanCancerResearchCenter,Heidelberg, Germany,9AgencyforPreventiveandSocialMedicine,Bregenz,Austria,10InstituteofPopulation-basedCancerResearch,TheCancerRegistryofNorway,Oslo,Norway, 11Department of Public Health and Clinical Medicine, Nutritional Research, Umea? University, Umea?, Sweden, 12Department of Radiation Sciences, Oncology, Umea? University,Umea?, Sweden Abstract Background:Prospectivestudieshaveindicatedthatelevatedbloodglucoselevelsmaybelinkedwithincreasedcancer risk,butthestrengthoftheassociationisunclear.Weexaminedtheassociationbetweenbloodglucoseandcancerriskina prospectivestudyofsixEuropeancohorts. MethodsandFindings:TheMetabolicsyndromeandCancerproject(Me-Can)includescohortsfromNorway,Austria,and Sweden; the current study included 274,126 men and 275,818 women. Mean age at baseline was 44.8 years and mean follow-uptimewas10.4years.Excludingthefirstyearoffollow-up,18,621menand11,664womenwerediagnosedwith cancer,and6,973menand3,088womendiedofcancer.WeusedCoxregressionmodelstocalculaterelativerisk(RR)for glucoselevels,andincludedadjustmentforbodymassindex(BMI)andsmokingstatusintheanalyses.RRs