Blueberry Husks and Probiotics Attenuate Colorectal Inflammation and Oncogenesis, and Liver Injuries in Rats Exposed to Cycling DSS-Treatment 英文参考文献.docVIP

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Blueberry Husks and Probiotics Attenuate Colorectal Inflammation and Oncogenesis, and Liver Injuries in Rats Exposed to Cycling DSS-Treatment 英文参考文献.doc

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Blueberry Husks and Probiotics Attenuate Colorectal Inflammation and Oncogenesis, and Liver Injuries in Rats Exposed to Cycling DSS-Treatment 英文参考文献

BlueberryHusksandProbioticsAttenuateColorectal InflammationandOncogenesis,andLiverInjuriesinRats ExposedtoCyclingDSS-Treatment Asa? Ha?kansson1*,CamillaBra¨nning2,Go¨ranMolin1,DiyaAdawi3,Marie-LouiseHagsla¨tt1, BengtJeppsson3,MargaretaNyman2,SivAhrne′1 1FoodHygiene,DivisionofAppliedNutritionandFoodChemistry,LundUniversity,Lund,Sweden,2DivisionofAppliedNutritionandFoodChemistry,LundUniversity, Lund,Sweden,3DepartmentofSurgery,LundUniversity,Ska?ne UniversityHospital,Malmo¨,Sweden Abstract Long-termcolonicinflammationpromotescarcinogenesisandhistologicalabnormalitiesoftheliver,andcolorectaltumours frequently arise in a background of dysplasia, a precursor of adenomas. Altered colonic microbiota with an increased proportion of bacteria with pro-inflammatory characteristics, have been implicated in neoplastic progression. The compositionofthemicrobiotacanbemodifiedbydietarycomponentssuchasprobiotics,polyphenolsanddietaryfibres.In the present study, the influence of probiotics in combination with blueberry husks on colorectal carcinogenesis and subsequent liver damage was evaluated. Colorectal tumours were induced in rats by cyclic treatment with dextran sulphate sodium (DSS). Blueberry husks and a mixture of three probiotic strains (Bifidobacterium infantis DSM 15159, Lactobacillusgasseri,DSM16737andLactobacillusplantarumDSM15313)supplementedabasicdietfortifiedwithoats.The condition of the rats was monitored using a disease activity index (DAI). A qualitative and quantitative histological judgement was performed on segments of distal colon and rectum and the caudate lobe of the liver. The formation of short-chain fatty acids, bacterial translocation, the inflammatory reaction and viable count of lactobacilli and Enterobaceriaceae were addressed. Blueberry husks with or without probiotics significantly decreased DAI, and significantlyreducedthenumberofcoloniculcersanddysplasticlesions.Withadecreasedproportionofblueberryhusk in the diet, the probiotic suppleme