BMI, Diet and Female Reproductive Factors as Risks for Thyroid Cancer A Systematic Review 英文参考文献.docVIP

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BMI, Diet and Female Reproductive Factors as Risks for Thyroid Cancer A Systematic Review 英文参考文献.doc

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BMI, Diet and Female Reproductive Factors as Risks for Thyroid Cancer A Systematic Review 英文参考文献

BMI,DietandFemaleReproductiveFactorsasRisksfor ThyroidCancer:ASystematicReview EmilyPeterson1,PrithwishDe1,2*,RobertNuttall2 1UniversityofToronto,DallaLanaSchoolofPublicHealth,DivisionofEpidemiology,Toronto,Ontario,Canada,2CanadianCancerSociety,CancerControlPolicy,Toronto, Ontario,Canada Abstract Background:Thyroidcancerincidencerateshavebeenincreasingworldwidebutthereasonbehindthisisunclear.Boththe increasing useof diagnostic technologies allowingthe detectionof thyroid cancer and atrue increase in thyroid cancer incidencehavebeenproposed.Thisreviewassessestheroleofbodymassindex(BMI),diet,andreproductivefactorsonthe thyroidcancertrend. Methods:EpidemiologicstudiesoftheselectedriskfactorsuptoJune2010werereviewedandcriticallyassessed. Results:Amongthethirty-sevenstudiesreviewedanddespitevariationintheriskestimates,mostpaperssupportedasmall but positive association for BMI (risk estimate range: 1.1–2.3 in males and 1.0–7.4 in females.). Among specific dietary components,therewasnoconsistentassociationofthyroidcancerriskwithiodineintakethroughfortification(riskestimate range: 0.49–1.6) or fish consumption (risk estimate range 0.6–2.2), nor with diets high in cruciferous vegetables (risk estimaterange0.6–1.9).Asmallnumberofstudiesshowedaconsistentprotectiveeffectofdietshighinnon-cruciferous vegetable (risk estimate range: 0.71–0.92). Among reproductive factors (pregnancy, parity, number of live births, use of prescriptionhormones,menstrualcycleregularity,andmenopausalstatus),nonewereconsistentlyassociatedwithhigher thyroidcancerrisk. Conclusions:BMIhadthestrongestlinktothyroidcancerriskamongthoseexamined.Detailedexaminationsofpopulation- levelriskfactorscanhelpidentifyandsupportpreventioneffortstoreducetheburdenofthyroidcancer. Citation:PetersonE,DeP,NuttallR(2012)BMI,DietandFemaleReproductiveFactorsasRisksforThyroidCancer:ASystematicReview.PLoSONE7(1):e29177. doi:10.1371/journal.pone.0029177 Editor:MarianLudgate,CardiffUniversity,UnitedKingdom ReceivedJuly6,2011;Acce