Biomimetic, Mild Chemical Synthesis of CdTe-GSH Quantum Dots with Improved Biocompatibility 英文参考文献.docVIP

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Biomimetic, Mild Chemical Synthesis of CdTe-GSH Quantum Dots with Improved Biocompatibility 英文参考文献.doc

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Biomimetic, Mild Chemical Synthesis of CdTe-GSH Quantum Dots with Improved Biocompatibility 英文参考文献

Biomimetic,MildChemicalSynthesisofCdTe-GSH QuantumDotswithImprovedBiocompatibility Jose′ M.Pe′rez-Donoso1,2*,JuanP.Monra′s1,2,DenisseBravo3,AdamAguirre3,AndrewF.Quest3,IgorO. Osorio-Roma′n4,RicardoF.Aroca5,ThomasG.Chasteen6,ClaudioC.Va′squez1* 1LaboratoriodeMicrobiolog?′aMolecular,DepartamentodeBiolog?′a,FacultaddeQu?′micayBiolog?′a,UniversidaddeSantiagodeChile,Santiago,Chile,2Laboratoriode Bioqu?′mica, Facultad de Ciencias Qu?′micas y Farmace′uticas, Universidad de Chile, Santiago, Chile, 3Laboratorio de Comunicaciones Celulares, Centro de Estudios MolecularesdelaCe′lula (CEMC),Facultad deMedicina,Universidad deChile,Santiago, Chile, 4Departamento deQu?′micaInorga′nica, Facultad deQu?′mica,Pontificia UniversidadCato′licadeChile,Santiago,Chile,5MaterialsandSurfaceScienceGroup,FacultyofSciences,UniversityofWindsor,Windsor,Ontario,Canada,6Department ofChemistry,SamHoustonStateUniversity,Huntsville,Texas,UnitedStatesofAmerica Abstract Multipleapplicationsofnanotechnology,especiallythoseinvolvinghighlyfluorescentnanoparticles(NPs)orquantumdots (QDs)havestimulatedtheresearchtodevelopsimple,rapidandenvironmentallyfriendlyprotocolsforsynthesizingNPs exhibitingnovelpropertiesandincreasedbiocompatibility. Inthisstudy,asimpleprotocolforthechemicalsynthesisof glutathione(GSH)-cappedCdTeQDs(CdTe-GSH)resemblingconditionsfoundinbiologicalsystemsisdescribed.Usingonly CdCl2,K2TeO3andGSH,highlyfluorescentQDswereobtainedunderpH,temperature,bufferandoxygenconditionsthat allow microorganisms growth. These CdTe-GSH NPs displayed similar size, chemical composition, absorbance and fluorescencespectraandquantumyieldsasQDssynthesizedusingmorecomplicatedandexpensivemethods. CdTeQDs were not freely incorporated into eukaryotic cells thus favoring their biocompatibility and potential applications in biomedicine. In addition, NPs entry was facilitated by lipofectamine, resulting in intracellular fluorescence and a slight increaseincelldeathbynecrosis.ToxicityoftheaspreparedCdTeQD