Biophysical Parameters Modification Could Overcome Essential Hearing Gaps 英文参考文献.docVIP

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Biophysical Parameters Modification Could Overcome Essential Hearing Gaps 英文参考文献.doc

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Biophysical Parameters Modification Could Overcome Essential Hearing Gaps 英文参考文献

BiophysicalParametersModificationCouldOvercome EssentialHearingGaps A.Kern1,C.Heid1,W.-H.Steeb2,N.Stoop2,3,R.Stoop1,2 * 1InstituteofNeuroinformatics,UniversityandSwissFederalInstituteofTechnologyZurich,Zu¨rich,Switzerland,2InternationalSchoolofScientificComputing,University ofJohannesburgAuckland,SouthAfrica,3ComputationalPhysics,SwissFederalInstituteofTechnologyZurich,Zu¨rich,Switzerland Abstract A majority of hearing defects are due to malfunction of the outer hair cells (OHCs), those cells within the mammalian hearingsensor(thecochlea)thatprovideanactiveamplificationoftheincomingsignal.Malformationofthehearingsensor, ototoxicdrugs,acousticaltrauma,infections,ortheeffectofagingaffectoftenawholefrequencyinterval,whichleadstoa substantial loss of speech intelligibility. Using an energy-based biophysical model of the passive cochlea, we obtain an explicitdescriptionofthedependenceofthetonotopicmaponthebiophysicalparametersofthecochlea.Ourfindings indicatethepossibilitythatbysuitablelocalmodificationsofthebiophysicalparametersbymicrosurgery,evenverysalient gapsofthetonotopicmapcouldbebridged. Citation:KernA,HeidC,SteebW-H,StoopN,StoopR(2008)BiophysicalParametersModificationCouldOvercomeEssentialHearingGaps.PLoSComputBiol4(8): e1000161.doi:10.1371/journal.pcbi.1000161 Editor:StefanoBoccaletti,IstitutoNazionalediOtticaApplicata,Italy ReceivedFebruary4,2008;AcceptedJuly16,2008;PublishedAugust29,2008 Copyright:?2008Kernetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:TheworkwassupportedbytheSwissNationalScienceFoundationandaZNZgrantfromUniversity/ETHofZurich. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:ruedi@ini.phys.ethz.ch Introduction bifurcation pointontheotherhand(theclosertothebifurcation point, the stronger the amplification). A biophysiologically detailed mod