Blueberry-Enriched Diet Protects Rat Heart from Ischemic Damage 英文参考文献.docVIP

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Blueberry-Enriched Diet Protects Rat Heart from Ischemic Damage 英文参考文献.doc

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Blueberry-Enriched Diet Protects Rat Heart from Ischemic Damage 英文参考文献

Blueberry-EnrichedDietProtectsRatHeartfromIschemic Damage IsmayilAhmet1,EdwardSpangler2,BarbaraShukitt-Hale3,MagdalenaJuhaszova1,StevenJ.Sollott1, JamesA.Joseph3,DonaldK.Ingram2,4,MarkTalan1* 1Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America, 2Laboratory of ExperimentalGerontology,IntramuralResearchProgram,NationalInstituteonAging,NationalInstitutesofHealth,Baltimore,Maryland,UnitedStatesofAmerica,3USDA- ARS,HumanNutritionResearchCenteronAging,TuftsUniversity,Boston,Massachusetts,UnitedStatesofAmerica, 4NutritionalNeuroscienceandAgingLaboratory, PenningtonBiomedicalResearchCenter,LouisianaStateUniversitySystem,BatonRouge,Louisiana,UnitedStatesofAmerica Abstract Objectives:toassessthecardioprotectivepropertiesofablueberryenricheddiet(BD). Background:Reactiveoxygenspecies(ROS)playamajorroleinischemia-relatedmyocardialinjury.Theattemptstouse syntheticantioxidantstoblockthedetrimentaleffectsofROShaveproducedmixedornegativeresultsprecipitatingthe interestinnaturalproducts.Blueberriesarereadilyavailableproductwiththehighestantioxidantcapacityamongfruitsand vegetables. MethodsandResults:Following3-moofBDoraregularcontroldiet(CD),thethresholdformitochondrialpermeability transition(tMPT)wasmeasuredinisolatedcardiomyocytesobtainedfromyoungmaleFischer-344rats.ComparedtoCD,BD resultedina24%increase(p,0.001)ofROSindexedtMPT.Theremaininganimalsweresubjectedtoapermanentligationof theleftdescendingcoronaryartery.24hrslaterresultingmyocardialinfarction(MI)inratsonBDwas22%lessthaninCD rats(p,0.01).SignificantlylessTUNEL(+)cardiomyocytes(2%vs9%)and40%lessinflammationcellswereobservedinthe myocardialareaatriskofBDcomparedtoCDrats(p,0.01).Inthesubgroupofrats,aftercoronaryligationtheoriginaldiet waseithercontinuedorswitchedtotheoppositeone,andcardiacremodelingandMIexpansionwerefollowedbyserial echocardiographyfor10weeks.MeasurementssuggestedthatcontinuationofBDoritswithdrawalafterMIat