Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease A Meta-Analysis 英文参考文献.docVIP

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Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease A Meta-Analysis 英文参考文献.doc

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Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease A Meta-Analysis 英文参考文献

BodyMassIndexandMortalityinChronicObstructive PulmonaryDisease:AMeta-Analysis ChaoCao1,2,RanWang1,JianmiaoWang1,HansvinBunjhoo1,YongjianXu1,WeiningXiong1* 1Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Department of RespiratoryMedicine,AffiliatedHospital,MedicalCollege,NingboUniversity,Ningbo,China Abstract Background:Theassociationbetweenbodymassindex(BMI)andmortalityinpatientssufferingfromchronicobstructive pulmonarydisease(COPD)hasbeenasubjectofinterestfordecades.However,theevidenceisinadequatetodrawrobust conclusionsbecausesomestudiesweregenerallysmallorwithashortfollow-up. Methods: We carried outasearch in MEDLINE, Cochrane CentralRegister ofControlled Trials, andEMBASE database for relevantstudies.Relativerisks(RRs)with95%confidenceinterval(CI)werecalculatedtoassesstheassociationbetweenBMI andmortalityinpatientswithCOPD.Inaddition,abaselinerisk-adjustedanalysiswasperformedtoinvestigatethestrength ofthisassociation. Results:22studiescomprising21,150participantswereincludedinthisanalysis.Comparedwithpatientshavinganormal BMI,underweightindividualswereassociatedwithhighermortality(RR =1.34,95%CI =1.01–1.78),whereasoverweight (RR =0.47,95%CI =0.33–0.68)andobese(RR =0.59,95%CI =0.38–0.91)patientswereassociatedwithlowermortality.We furtherperformedabaselinerisk-adjustedanalysisandobtainedstatisticallysimilarresults. Conclusion: Our study showed that for patients with COPD being overweight or obese had a protective effect against mortality.However,therelationshipbetweenBMIandmortalityindifferentclassesofobesityneededfurtherclarificationin well-designedclinicalstudies. Citation:CaoC,WangR,WangJ,BunjhooH,XuY,etal.(2012)BodyMassIndexandMortalityinChronicObstructivePulmonaryDisease:AMeta-Analysis.PLoS ONE7(8):e43892.doi:10.1371/journal.pone.0043892 Editor:ColinSimpson,TheUniversityofEdinburgh,UnitedKingdom ReceivedNovember24,2011;AcceptedJuly26,2012;PublishedAugust24,20