Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake 英文参考文献.docVIP

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Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake 英文参考文献.doc

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Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake 英文参考文献

BreastCancerDNAMethylationProfilesAreAssociated withTumorSizeandAlcoholandFolateIntake BrockC.Christensen1,2,KarlT.Kelsey1,2,ShichunZheng3,E.AndresHouseman2,4,CarmenJ.Marsit1,2 MargaretR.Wrensch3,JosephL.Wiemels5,HeatherH.Nelson6,MargaretR.Karagas7,LawrenceH. Kushi8,MarilynL.Kwan8,JohnK.Wiencke3* , 1DepartmentofPathologyandLaboratoryMedicine,BrownUniversity,Providence,RhodeIsland,UnitedStatesofAmerica,2DepartmentofCommunityHealth,Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United States of America, 3Department of Neurological Surgery, Helen Diller FamilyCancerCenter,UniversityofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesofAmerica,4DepartmentofBiostatistics,HarvardSchoolofPublic Health,Boston,Massachusetts,UnitedStatesofAmerica,5DepartmentofEpidemiologyandBiostatistics,UniversityofCaliforniaSanFrancisco,SanFrancisco,California, UnitedStatesofAmerica,6MasonicCancerCenter,DivisionofEpidemiologyandCommunityHealth,UniversityofMinnesota,Minneapolis,Minnesota,UnitedStatesof America, 7Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire, United StatesofAmerica,8DivisionofResearch,KaiserPermanente,Oakland,California,UnitedStatesofAmerica Abstract Althoughtumorsizeandlymphnodeinvolvementarethecurrentcornerstonesofbreastcancerprognosis,theyhavenot beenextensivelyexploredinrelationtotumormethylationattributesinconjunctionwithothertumorandpatientdietary andhormonalcharacteristics.Usingprimarybreasttumorsfrom162(AJCCstageI–IV)womenfromtheKaiserDivisionof Research Pathways Study and the Illumina GoldenGate methylation bead-array platform, we measured 1,413 autosomal CpGlociassociatedwith773cancer-relatedgenesandvalidatedselectCpGlociwithSequenomEpiTYPER.Tumorgrade, size,estrogenandprogesteronereceptorstatus,andtriplenegativestatusweresignificantly(Q-values,0.05)associated with altered methylation of 209, 74, 183, 69, and 130 loci, re